Abstract
Isolated coronary ectatic but otherwise normal epicardial coronary arteries are an infrequent angiographic finding. We sought to determine whether coronary artery ectasia (CAE) may alter QT-interval duration and dispersion. The study population consisted of 24 patients with isolated CAE and otherwise normal epicardial coronary arteries (group 1) and sex- and age-matched subjects with atypical chest pain and otherwise normal coronary flow (group 2). Both groups underwent a routine standard 12-lead surface electrocardiogram recorded at 50 mm/s during rest. QT dispersion (QTd), corrected QT (QTc), and corrected QT dispersion (QTcd) were calculated. Distribution of sex, age, body mass index, and cardiac risk factors were similar in the 2 groups. Mean heart rate was similar in the 2 groups (74 +/- 10 vs 70 +/- 7, P > .05). In group 1, QTd, QTcd, and QTc were significantly higher than those of group 2 (QTd, 40 +/- 17 vs 29 +/- 10 milliseconds [P < .05]; QTcd, 43 +/- 19 vs 30 +/- 10 milliseconds [P < .05]; QTc, 410 +/- 21 vs 397 +/- 19 milliseconds [P < .05]). In conclusion, CAE was found to be associated with prolonged QT interval and increased QTd. Microvascular dysfunction and/or ischemia may be responsible mechanisms.
References
Apr 1, 1977·The American Journal of Medicine·B BefelerR Lazzara
May 1, 1976·Chest·H L Falsetti, R J Carrol
Jun 1, 1990·British Heart Journal·C P DayR W Campbell
Apr 1, 1985·American Heart Journal·S RathH N Neufeld
Oct 1, 1985·British Heart Journal·G G HartnellR B Pridie
Jan 1, 1981·British Heart Journal·M J Davies
Jan 1, 1983·Circulation·P S SwayeA J Gosselin
Jun 1, 1994·British Heart Journal·M PyeS M Cobbe
Sep 15, 1994·The American Journal of Cardiology·W ZarebaS le Cessie
Mar 1, 1993·Japanese Heart Journal·M J Hashemi, A A Petrossians
May 1, 1993·Angiology·A TomaruN Nishiyama
Mar 7, 1998·Circulation·M C de BruyneD E Grobbee
Oct 24, 1998·Journal of Cardiovascular Electrophysiology·W L AtigaR D Berger
Mar 23, 1999·Circulation·J A KorsJ H van Bemmel
Jun 1, 2001·Japanese Heart Journal·K NagataS Katoh
Nov 13, 2001·The American Journal of Cardiology·M C PapadakisD V Cokkinos
Jan 7, 2003·American Heart Journal·Omer AkyürekDerviş Oral
Dec 20, 2003·Heart and Vessels·Kubilay SenenSengul Cehreli
Sep 22, 2005·Journal of Cardiovascular Electrophysiology·Peter M OkinRichard B Devereux