Effects of isolated positive maternal thyroglobulin antibodies on brain development of offspring in an experimental autoimmune thyroiditis model

Thyroid : Official Journal of the American Thyroid Association
Xinyi WangWeiping Teng

Abstract

Autoimmune thyroiditis (AIT) is a very common endocrine disorder in pregnancy. However, the effect of maternal positive thyroglobulin antibodies (TgAb) on brain development of offspring remains unclear. This study used an experimental autoimmune thyroiditis model in CBA/J mice and determined whether isolated positive maternal TgAb directly affected learning and memory abilities of offspring. An experimental autoimmune thyroiditis model was established in CBA/J mice through immunization with murine thyroglobulin (mTg). Measuring thyroid function and serum TgAb titer confirmed the presence of isolated positive maternal TgAb. Offspring serum TgAb titer, MCT8, Reelin, RC3, and BNDF mRNA expression in the brain, and brain histology were measured on postnatal days 0, 10, and 40 (PND0, PND10, PND40), and nerve cell migration (BrdU labeling) at PND40. Morris water maze, long-term potentiation (LTP), and LTP-related factor ERK1/2 levels were measured at PND40 to determine offspring spatial learning and memory development. Maternal serum TgAb titers increased and remained elevated through pregnancy compared to controls. Thyrotropin and thyroid hormone levels were normal. The T group offspring (Tg immunized) had higher TgAb titers than th...Continue Reading

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Citations

Oct 31, 2018·Journal of Neuroinflammation·Yao-Jun CaiDe-Fa Zhu
Apr 10, 2019·Thyroid : Official Journal of the American Thyroid Association·Cheng HanWeiping Teng
Feb 1, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jiufei DuanMingqing Chen
Sep 11, 2020·Thyroid : Official Journal of the American Thyroid Association·Nan WangFen Wang
Nov 3, 2020·Therapeutic Advances in Endocrinology and Metabolism·Samantha AnandappaPaul V Carroll
Mar 11, 2021·Risk Management and Healthcare Policy·Chuyu LiLing Wang

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
Protein Assay
ELISA
PCR

Software Mentioned

Pro
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Image

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