PMID: 7992464Jan 1, 1994Paper

Effects of isoniazid (INH) on the BCG-induced local immune response after intravesical BCG therapy for superficial bladder cancer

Urological Research
M J StassarW den Otter

Abstract

Because recent investigations showed that the use of isoniazid (INH) severely impaired the local immune reaction to intravesical bacillus Calmette-Guérin (BCG) in the bladder of guinea pigs, in this study the effect of INH in man has been investigated. Patients were treated with BCG with or without oral INH. The concentration of free INH in most urine samples of patients treated with BCG/INH was much higher (mean 38.0 +/- 60.9 micrograms INH/ml) than the minimal inhibitory concentration (MIC; 0.1 microgram INH/ml), suggesting at least a bacteriostatic potential of the INH present. However, in vitro studies showed that these urinary concentrations of INH did not kill BCG organisms effectively, even at a concentration of 150 micrograms/ml for 24 h. After the fifth and sixth BCG instillations a significant increase in the concentration of cytokines (IL2, IL6, IL8 and TNFa), IgG and IgA antibodies to BCG and the number of leukocytes in urine was observed. The leukocytes mainly consisted of granulocytes, besides monocytes/macrophages and, in lower amounts, T- and B-lymphocytes and natural killer (NK) cells. The absolute number of granulocytes and the concentration of IgG antibodies after BCG instillation were significantly suppresse...Continue Reading

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Citations

Sep 30, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·A BöhleA J Ulmer
Dec 7, 2013·Journal of Immunotoxicology·Imir G Metushi, Jack Uetrecht
Nov 24, 1999·The Journal of Urology·C DurekA Böhle
Jun 1, 1997·Scandinavian Journal of Urology and Nephrology·C P Hansen, S Mortensen
Sep 1, 1997·Seminars in Surgical Oncology·U O Nseyo, D L Lamm
Apr 20, 2000·The Annals of Pharmacotherapy·J J Menke, J R Heins

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