Effects of isoprenaline, levodopa and a phosphodiesterase inhibitor (ICI 63,197) on cyclic AMP levels and contractions of soleus muscles in anesthetized cats

Clinical and Experimental Pharmacology & Physiology
Z Merican, M W Nott

Abstract

1. Cyclic AMP levels have been determined in the soleus muscles of anaesthetized cats in the absence of drugs, and during depression of incomplete tetanic contractions produced by (-)-isoprenaline, ICI 63,197 (a phosphodiesterase inhibitor) or levodopa. 2. Cyclic AMP levels were elevated at the peak of tension depression produced by isoprenaline. Effects of isoprenaline on cyclic AMP and on contractions were dose dependent and statistically significantly related one to the other. Both effects were blocked by propranolol. 3. ICI 63,197 and levodopa produced isoprenaline-like effects on contractions but times to peak effect and recovery were longer. Cyclic AMP levels estimated during the depressant action were elevated. 4. The results support the involvement of cyclic AMP in the depressant effect of beta-adrenoreceptor agonists on slow-contracting mammalian skeletal muscle.

Citations

Sep 1, 1977·The Journal of Pharmacy and Pharmacology·B Waldeck
Jul 1, 1978·Clinical and Experimental Pharmacology & Physiology·W C BOWMAN, M W Nott
Dec 1, 1970·The Biochemical Journal·A R SomervilleA A Smith
Apr 15, 1971·Life Sciences. Pt. 1: Physiology and Pharmacology·M J Schmidt, G A Robison
Mar 20, 1971·British Medical Journal·J S LeggeK N Palmer
Jun 1, 1974·Life Sciences·A J TurnerS Garattini
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Related Concepts

Phosphodiesterase Inhibitors
Contraction (Finding)
Cyclic AMP
Triazoles
Soleus Muscle Structure
Anesthesia Procedures
Cyclic Adenosine Monophosphate Measurement
Illusions
Adrenergic Receptor
Novodrin

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