Jun 1, 1976

Effects of isoproterenol on cyclic-AMP metabolism in rat ventral prostate

Canadian Journal of Physiology and Pharmacology
B K Tsang, R L Singhal


Beta-Adrenergic stimulation of the ventral prostate cyclic-AMP system was investigated by examining the influence of isoproterenol on endogenous cyclic-AMP levels as well as on the activities of adenylate cyclase CEC and cyclic-AMP-dependent and independent protein kinases (EC Administration of isoproterenol (1 mg/kg, ip) resulted in rapid elevation of adenylate cyclase activity (119%) and cyclic-AMP levels (593%). The observed isoproterenol-stimulated changes in cyclic-AMP metabolism of the ventral prostate were time-dependent and maximal stimulation was seen 5 min after treatment with this beta-adrenergic agonist. The increases in prostatic adenylate cyclase and cyclic-AMP also were related to the dose of isoproterenol administered and maximal enhancement of these parameters was seen with 1 mg/kg dose of the agonist. Whereas pretreatment of rats with propranolol (3mg/kg, ip) partially reversed these alterations, administration of an alpha-adrenergic antagonist, phentolamine, even at a dose of 5 mg/kg, failed to elicit any appreciable effect. Stimulation of prostatic soluble protein kinase by isoproterenol was associated with a decrease (33%) in the activity of the cyclic-AMP-dependent protein kinase with a...Continue Reading

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Mentioned in this Paper

AMP Metabolic Process
LIM Domain Kinase 1
AMP Binding
Cyclic AMP
Adrenergic beta-Agonists
Adrenergic alpha-Antagonists
3-Phosphoinositide Dependent Protein Kinase-1

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