Effects of isovolemic hemodilution on hemodynamics, cerebral perfusion, and cerebral vascular reactivity

Stroke; a Journal of Cerebral Circulation
Y K Tu, H M Liu

Abstract

To verify the hemorheological effects of isovolemic hemodilution on hemodynamics and cerebral perfusion of normal humans, we tested the efficacy of isovolemic hemodilution in systemic hemodynamics and cerebral bood flow augmentation and its influences in vascular reserve. Isovolemic hemodilution was studied in a total of 13 normal healthy subjects. Regional cerebral blood flow was measured by the xenon-enhanced CT method. Cerebral vascular activity was measured by acetazolamide challenge. These measurements, in association with hemorheological and hemodynamic monitoring, were analyzed before and after isovolemic hemodilution with low-molecular-weight dextran. Our results showed significant change in hemodynamic parameters after isovolemic hemodilution, including tachycardia, a 24% increase of cardiac index, and decrease of peripheral vascular resistance. Both left and right heart work index increased as a consequence of increased cardiac index. Regional cerebral blood flow increased 35.0 +/- 2.5% at 3 hours after hemodilution and 20.2 +/- 3.9% at 1 week after hemodilution. Cerebral vascular reactivity decreased from 32.1 +/- 4.1% to 25.3 +/- 4.0% after hemodilution, implicating a certain degree of vasodilation in the process of...Continue Reading

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