PMID: 2116157Jun 1, 1990Paper

Effects of i.v. lignocaine on airway reflexes elicited by irritation of the tracheal mucosa in humans anaesthetized with enflurane

British Journal of Anaesthesia
T NishinoK Sugimori

Abstract

We have investigated the effects of bolus administration of lignocaine 1.5 mg kg-1 i.v. on respiratory responses to airway irritation induced by instillation of distilled water into the trachea in 10 patients anaesthetized with enflurane (1.5% end-tidal). Before administration of lignocaine, airway irritation elicited not only the cough reflex, but also other respiratory reflexes such as expiration, apnoea and spasmodic panting. Immediately after administration of i.v. lignocaine, when plasma concentrations of lignocaine exceeded 4.7 micrograms ml-1, tracheal irritation elicited only brief apnoea. Other reflex responses were suppressed completely; they recovered gradually with progressive decrease in plasma concentration of lignocaine. The apnoeic reflex was not eliminated at plasma lignocaine concentrations greater than 7.0 micrograms ml-1, whereas the expiration reflex, cough reflex and spasmodic panting were eliminated effectively by plasma concentrations of lignocaine greater than 3.5, 2.8 and 2.2 micrograms ml-1, respectively.

Citations

Mar 17, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·C J HuangT T Wei
Jun 1, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·W HirotaK Hirota
Feb 3, 2005·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Chandra Kant PandeyPrabhat Kumar Singh
May 10, 2005·Respiratory Physiology & Neurobiology·John Widdicombe, Vijay Singh
Oct 2, 2001·Journal of Clinical Anesthesia·P A MainlandC K Lai
Feb 2, 1999·American Journal of Respiratory and Critical Care Medicine·H GroebenJ Peters
Aug 21, 2013·Cough·Agreta Gecaj-GashiMusli Gashi
Jun 24, 2000·The Japanese Journal of Physiology·T Nishino
Feb 4, 2012·Journal of Clinical Anesthesia·Antje GottschalkDanja S Groves
Aug 4, 2009·Pulmonary Pharmacology & Therapeutics·Ewa-Lena JohanssonEva Millqvist
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Nov 27, 2004·Pulmonary Pharmacology & Therapeutics·T NishinoT Ishikawa
Jul 1, 1992·The Annals of Otology, Rhinology, and Laryngology·T M McCullochM J Bishop
Jul 2, 2011·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Jeremy P Hampton
Oct 26, 2005·Anesthesia and Analgesia·Jean-Pierre EstebeClaude Ecoffey
Dec 22, 2005·Anesthesia and Analgesia·Woon-Young KimHye-Ja Lim
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Aug 18, 2018·Drugs·Marc BeaussierLuc Mercadal
Dec 17, 2015·Veterinary Anaesthesia and Analgesia·Ambra PantiLouise Clark

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