Effects of ivabradine and metoprolol on cardiac angiogenesis and endothelial dysfunction in rats with heart failure

Journal of Cardiovascular Pharmacology
Nadir UluWiek H van Gilst

Abstract

Myocardial infarction (MI)-induced remodeling is associated with disturbed myocardial perfusion through vascular changes, such as reduced capillary density and endothelial dysfunction. Heart rate reduction (HRR) initiated immediately after MI stimulates angiogenesis and attenuates left ventricular dysfunction. We aimed to investigate the effects of long-term HRR on cardiac angiogenesis and endothelial function in a rat model of post-MI heart failure. Rats received early or late ivabradine or metoprolol for 12 or 9 weeks, respectively, and compared with untreated MI and sham animals 12 weeks after MI. Heart rate was measured in the conscious rat. MI resulted in an increased heart weight to body weight ratio, a decline in capillary density and a marked reduction in acetylcholine-induced relaxation. Early and late HRR by either ivabradine or metoprolol significantly increased capillary to myocyte ratio. Moreover, this ratio was significantly correlated to heart rate (r = -0.324 and P = 0.036). Neither early nor late chronic HRR prevented endothelial dysfunction, except a moderate improvement in late MI ivabradine group. In MI rats, HRR either by ivabradine or metoprolol treatment increases cardiac angiogenesis. Late HRR strategy w...Continue Reading

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Citations

Sep 14, 2012·Heart Failure Reviews·Maya Guglin
Apr 11, 2012·International Journal of Cancer. Journal International Du Cancer·Chenming MaWolfgang Kemmner
Oct 11, 2016·International Journal of Cardiology·Beatriz B LustosaPaula S Azevedo
Nov 24, 2016·Clinical Cardiology·John ZarifisUNKNOWN investigators of the Prospective, Non-interventional, Observational Study of the Antianginal Efficacy of Ivabradine During a
Feb 26, 2015·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Xiangfei WangJunbo Ge
Nov 2, 2015·Advances in Therapy·Antonio Carlos Pereira-Barretto
Jul 30, 2015·Journal of Cardiovascular Pharmacology·Nassiba MerabetPaul Mulder
Jul 25, 2020·Genetics and Molecular Biology·Hui LvYongwen Qin

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