Effects of ivabradine therapy on heart failure biomarkers

Cardiology Journal
Serkan OrduHakan Ozhan

Abstract

Heart rate (HR) reduction is associated with improved outcomes in patients with heart failure (HF) and biomarkers can be a valuable diagnostic tool in HF management. The primary aim of our study was to evaluate the short-term (6 months) effect of ivabradine on N-terminal pro B-type natriuretic peptide (NT-proBNP), CA-125, and cystatin-C values in systolic HF outpatients, and secondary aim was to determine the relationship between baseline HR and the NT-proBNP, CA-125, cystatin-C, and clinical status variation with ivabradine therapy. Ninety-eight patients (mean age: 65.81 ± 10.20 years; 33 men), left ventricular ejection fraction < 35% with Simpson method, New York Heart Association (NYHA) class II-III, sinus rhythm and resting HR > 70/min, optimally treated before the study were included. Among them, two matched groups were formed: the ivabradine group and the control group. Patients received ivabradine with an average (range of 10-15) mg/day during 6 months of follow-up. Blood samples for NT-proBNP, CA-125, and cystatin-C were taken at baseline and at the end of a 6-month follow-up in both groups. There was a significant decrease in NYHA class in the ivabradine group (2.67 ± ± 0.47 vs. 1.85 ± 0.61, p < 0.001). When ivabradine...Continue Reading

Citations

Dec 17, 2016·Journal of the American College of Cardiology·João Pedro FerreiraFaiez Zannad
May 11, 2019·Expert Opinion on Drug Safety·Edimar Alcides Bocchi, Vera Maria Cury Salemi
Jan 23, 2016·Current Heart Failure Reports·Gabriela OrasanuGuilherme H Oliveira
Sep 12, 2015·American Journal of Therapeutics·Ghazwan ShaayaRohit Arora
Oct 13, 2021·Canadian Journal of Physiology and Pharmacology·Noémi TóthNorbert Nagy

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