Effects of ivermectin on Danio rerio: a multiple endpoint approach: behaviour, weight and subcellular markers

Ecotoxicology
I DominguesM J B Amorim

Abstract

Ivermectin (IVM) is a broad acting antihelmintic used in various veterinary pharmaceuticals. It has been shown that IVM enters the aquatic compartment and adversely affects organisms including fish. This study is based on the hypothesis that long term exposure to IVM affects fish and thus, the main objective was to assess the chronic effects of 0.25 and 25 µg IVM/L to zebrafish using multiple endpoints representative of several levels of biological organization: weight, behaviour (swimming and feeding) and subcellular markers including biomarkers for oestrogenicity (vitellogenin-VTG), oxidative stress (catalase-CAT and glutathione-S-transferase-GST) and neurotransmission (cholinesterase-ChE). Concentrations as low as 0.25 µg IVM/L disrupted the swimming behaviour, causing fish to spend more time at the bottom of aquaria. Such reduction of the swimming performance affected the feeding ability which is likely responsible for the weight loss. The effects on weight were gender differentiated, being more pronounced in males (0.25 µg IVM/L) than in females (25 µg IVM/L). Fish exposed to 25 µg/L exhibited darker coloration and mild curvature of the spine. No effects on VTG and AChE were observed, but a reduction on CAT and GST levels ...Continue Reading

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Citations

May 8, 2016·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Rhaul OliveiraInês Domingues
Dec 25, 2016·Analytical and Bioanalytical Chemistry·Manuel WohdeRolf-Alexander Düring
Feb 18, 2020·Environmental Science and Pollution Research International·Íris Flávia Sousa GonçalvesDavi Felipe Farias
Apr 12, 2020·Environmental Science and Pollution Research International·Cristiane GarbinatoAnna Maria Siebel
Oct 20, 2020·Journal of Toxicology and Environmental Health. Part a·Valeska Toffolo MinskiAnna Maria Siebel
Feb 14, 2021·Chemosphere·Sandra F GonçalvesSusana Loureiro
Jan 13, 2021·Environmental Pollution·Ana Rita AlmeidaIsabel Henriques
Apr 4, 2021·International Journal of Environmental Research and Public Health·Ana Rita AlmeidaIsabel Henriques
Apr 19, 2021·Environmental Pollution·Marta Silva MunizDavi Farias

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