Effects of Japanese traditional medicines on circulating cytokine levels in women with hot flashes

Menopause : the Journal of the North American Menopause Society
Toshiyuki YasuiMinoru Irahara

Abstract

The effects of the Japanese traditional medicines keishibukuryogan and kamishoyosan on circulating cytokines were examined to clarify the difference in the actions of Japanese traditional medicines in women with hot flashes. Seven premenopausal, 51 perimenopausal, 45 spontaneously postmenopausal and 17 surgically postmenopausal women who had complained of hot flashes were enrolled in this study. Eighty women who hoped to receive Japanese traditional medicines were randomly assigned in open, parallel-group fashion to a keishibukuryogan group or kamishoyosan group. Forty women who did not want any treatment for hot flashes were followed up for 6 months as a control group. Serum levels of cytokines were measured using a multiplexed human cytokine assay. The proportions of responders in women treated with keishibukuryogan and kamishoyosan were 73.7% and 69.2%, respectively. Serum monocyte chemotactic protein-1 level in women treated with keishibukuryogan decreased significantly (P = 0.0037). On the other hand, concentrations of interleukin (IL)-6 and macrophage inflammatory protein-1β in women treated with kamishoyosan decreased significantly (P = 0.019 and P = 0.039, respectively). In both keishibukuryogan and kamishoyosan respond...Continue Reading

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Citations

Dec 17, 2015·Menopause : the Journal of the North American Menopause Society·Shu-fei FuXiu-mei Gao
Jul 11, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Guo-Shiou LiaoLie-Fen Shyur
May 29, 2018·Obstetrics and Gynecology International·Akihiko YoshimuraTadashi Kimura
Jul 27, 2018·Mediators of Inflammation·MuDan Cai, Eun Jin Yang
Jul 24, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Sunjung Park, Eun Jin Yang

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