PMID: 8600130Sep 1, 1995Paper

Effects of kanamycin ototoxicity and hair cell regeneration on the DC endocochlear potential in adult chickens

Hearing Research
L ChenR Salvi

Abstract

High doses of aminoglycoside antibiotics cause massive damage to the avian basilar papilla. The resulting functional loss could conceivably arise from the reduction in the DC endocochlear potential (EP) due to impairment of the tegmentum vasculosum (TV) or to shunting of current through the damaged sensory epithelium. To test this hypothesis, the EP was measured in adult chickens after destroying hair cells in the basal half of the cochlea with a high dose (400 mg/kg per day for 10 days) of kanamycin (KM). KM treatment caused an increase in the steady-state EP from +18.1 to +23.3 mV and a decrease in the magnitude of the negative EP from -42.0 to -19.2 mV. The EP showed almost no change between 1 and 2 days and 1 week post-KM treatment. After 4 weeks of recovery, most hair cells had regenerated; however, the steady-state EP was still elevated by 13% and the negative EP was depressed by 37%. These results suggest that functional loss as shown by the large reduction in cochlear microphonic (CM) and the elevated thresholds of compound action potential (CAP) following KM treatment is not due to a reduction in the EP but may arise from functional deficits in the hair cells and/or the auditory nerve.

References

May 1, 1979·Acta Oto-laryngologica·T Konishi
Jul 1, 1978·Acta Oto-laryngologica·Y Toyoda, M Tachibana
Feb 1, 1992·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·R J SalviF A Boettcher
Aug 22, 1990·Proceedings. Biological Sciences·P A Fuchs, B H Sokolowski
May 1, 1991·Hearing Research·R B Patuzzi, C L Bull
Jan 1, 1990·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·T Vossieck, R Klinke
Jan 1, 1989·The Journal of the Acoustical Society of America·E Hashino, M Sokabe
Mar 1, 1985·The Journal of the Acoustical Society of America·L Gray, E W Rubel
Jan 1, 1965·Cold Spring Harbor Symposia on Quantitative Biology·H Davis
Feb 1, 1995·The Journal of the Acoustical Society of America·S S SaundersK M Miller
Mar 1, 1994·Journal of Comparative Physiology. A, Sensory, Neural, and Behavioral Physiology·R J SalviL Chen
May 1, 1993·The Journal of Comparative Neurology·L G Duckert, E W Rubel
Jul 1, 1993·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·S KomuneT Uemura
Jul 1, 1993·The Journal of the Acoustical Society of America·S S Saunders, R J Salvi
Jun 1, 1962·Journal of Cellular and Comparative Physiology·R S SCHMIDT, C FERNANDEZ

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Citations

Feb 24, 2007·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Christine Köppl, Otto Gleich
Dec 18, 2001·Hearing Research·L ChenR J Salvi
Feb 21, 2003·Current Opinion in Neurobiology·Olivia Bermingham-McDonogh, Edwin W Rubel

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