PMID: 9194150May 1, 1997Paper

Effects of kawain and dihydromethysticin on field potential changes in the hippocampus

Progress in Neuro-psychopharmacology & Biological Psychiatry
J WaldenH Grunze

Abstract

1. The kava-pyrones kawain and dihydromethysticin are constituents of Piper methysticum which exert anticonvulsant, analgesic and anxiolytic properties. 2. In the present study the effect of these kava-pyrones were tested on field potential changes (fp) induced by omission of the extracellular Mg2+, recorded from the area CA1 and CA3 of the hippocampal slice preparation of guinea pigs. These fp are generated by an activation of NMDA receptors and voltage dependent calcium channels. 3. Kawain and dihydromethysticin reduced reversibly the frequency of occurrence of fp in a concentration range from 5 to 40 mumol/l and 10 to 40 mumol/l, respectively. 4. Reduction of the fp frequency after addition of subthreshold concentrations of 5 mumol/l kawain and 10 mumol/l dihydromethysticin indicated additive actions of both drugs. 5. Since the serotonin-1A agonist ipsapirone also exerts anxiolytic effects, subthreshold concentrations of kawain or dihydromethysticin were combined with a subthreshold concentration of ipsapirone in another set of experiments. Combining kawain and ipsapirone or dihydromethysticin and ipsapirone caused a reduction of the rate of fp to 0.76 and 0.81 of the baseline value, respectively. 6. The findings suggest tha...Continue Reading

References

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Citations

Sep 25, 2002·Life Sciences·Anna Rita BiliaFranco F Vincieri
Oct 20, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·H GrunzeJ Walden
Nov 26, 1998·Progress in Neuro-psychopharmacology & Biological Psychiatry·S S BaumH Rommelspacher
Apr 26, 2000·Brain Research Bulletin·I KovácsJ Kardos
May 15, 1998·Journal of Ethnopharmacology·M A McFerren, E Rodriguez
Mar 19, 1999·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·K SchirrmacherD Bingmann
Sep 13, 2002·The Australian and New Zealand Journal of Psychiatry·Sheree CairneyAlan R Clough
Jul 28, 2004·Journal of Herbal Pharmacotherapy·Ethan BaschEdzard Ernst
Jul 14, 2005·Expert Opinion on Drug Safety·Catherine UlbrichtStephen Bent
Jun 29, 2005·Journal of Psychopharmacology·David Wheatley
Oct 31, 2002·Human Psychopharmacology·David Wheatley
Oct 18, 2002·CNS Drugs·Yadhu N Singh, Nirbhay N Singh
May 3, 2013·Journal of Clinical Psychopharmacology·Jerome SarrisIsaac Schweitzer
Dec 10, 2019·The Australian and New Zealand Journal of Psychiatry·Jerome SarrisCon Stough
Aug 31, 2004·CNS Spectrums·K M ConnorL E Churchill
Oct 9, 2020·Nutrients·Tengfei BianChengguo Xing
Jan 7, 2020·ACS Chemical Neuroscience·Andrey VolginAllan Kalueff

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