PMID: 7086066Mar 1, 1982Paper

Effects of ketamine and Althesin Anesthesia on baroreceptor--heart rate reflex and hemodynamics of intact and pontine rabbits

Journal of the Autonomic Nervous System
D W Blake, P I Korner

Abstract

The changes in baroreceptor-heart rate reflex properties and in hemodynamics produced by light ketamine anesthesia were studied in one group of rabbits before and after infracollicular decerebration and those produced by althesin anesthesia in another group. Ketamine produced marked depression of baroreceptor reflex-mediated vagal effects on heart rate which was of similar magnitude in intact and pontine decerebrate rabbits; this indicates that its action was largely at or below the pons. Althesin produced much less vagal depression than ketamine in the intact rabbit but in pontine rabbits the depression was greatly enhanced. The smaller vagal depression in the intact rabbit appears to be due to a facilitatory effect through a suprapontine pathway by Althesin which partially masks its depressant effect below the pons. In the intact rabbit ketamine produced a greater rise in blood pressure than Althesin anesthesia for 1 h; the greater pressor response was due to a transient rise in total peripheral resistance (TPR) and a sustained rise in cardiac output. The difference in the blood pressure responses was mainly due to differences in action of the two anesthetics at or below the pons and only the transient rise in TPR during keta...Continue Reading

Citations

Jul 31, 2001·Autonomic Neuroscience : Basic & Clinical·A AkineY Kato
Jun 9, 2000·Kidney International·M E Van TeijlingenG J Tangelder
Oct 1, 1994·Clinical and Experimental Pharmacology & Physiology·G A Head
Jan 23, 2010·Journal of Applied Physiology·W Michael PannetonRajko Juric
Jun 11, 2016·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Diana Mihova, Julio C Hechavarría
May 1, 2002·Anesthesiology·Jong S LeeKyoung S K Chang
May 25, 2004·Journal of Applied Physiology·Evguenia BouairiDavid Mendelowitz
Apr 7, 2021·Veterinary Anaesthesia and Analgesia·Eva M GreunzMads F Bertelsen

Related Concepts

Saffan
General Anesthesia
Metazoa
Diastolic Blood Pressure
Cardiac Output
Decorticate State
Pulse Rate
Ketaset
Pontine Structure
Pressoreceptors

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