PMID: 3756149Sep 25, 1986Paper

Effects of ketamine anesthesia on rat-brain membranes: fluidity changes and kinetics of acetylcholinesterase

Biochimica Et Biophysica Acta
L MazzantiG Lenaz

Abstract

This investigation shows that the effects of general anesthetics previously observed in vitro on membrane fluidity and on enzymic activities and occurring at concentrations calculated to be clinically relevant can be reproduced in vivo in anesthetized animals. Anesthesia with 2-chlorophenyl-2-methylaminocyclohexanone (ketamine) induces a more fluid state of rat-brain synaptic and mitochondrial membranes, as shown by the rotational correlation times of the spin labels 16-doxylstearate and 5-doxylstearate. Changes in acetylcholinesterase activity, with a decrease in Vmax and no change in the Km for acetylcholine, closely follow the fluidity increase.

Citations

Jul 20, 2002·Brain Research Bulletin·Kunjan R DaveSurendra S Katyare
May 12, 2017·Brazilian Journal of Biology = Revista Brasleira De Biologia·J SalbegoB Baldisserotto

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