PMID: 1218141Nov 1, 1975Paper

Effects of ketamine on central sympathetic discharge and the baroreceptor reflex during mechanical ventilation

British Journal of Anaesthesia
J C McGrathR A Millar


In rabbits which were ventilated mechanically, with a background anaesthetic of pentobarbitone or after decerebration, ketamine depressed preganglionic sympathetic activity and arterial pressure. Conduction through central baroreceptor pathways, tested by depressor nerve stimulation, showed a selective inhibition of the heart rate response.


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