PMID: 9163274Mar 1, 1997Paper

Effects of ketamine on CNS-function

Der Anaesthesist
O Detsch, E Kochs

Abstract

The present review summarises the main actions of racemic ketamine and ketamine enantiomers on central nervous system receptors. The primary CNS action of ketamine appears to be a non-competitive block of N-methyl-D-aspartate receptors. Although numerous other receptors (e.g., GABA, nicotinic acetylcholine, opiate, voltage-operated channels) have been reported to interact with ketamine, their role in inducing dissociative anaesthesia is still under discussion. In humans, characteristic electroencephalographic (EEG) changes after administration of ketamine are dose-dependent increases in delta, theta, and beta power. In equipotent doses S-(+)-ketamine induces similar EEG changes. However, in comparison to racemic ketamine and S-(+)-ketamine, R-(-)-ketamine does not suppress the EEG to the same extent. Former studies suggested that ketamine is a proconvulsive agent; however, recent studies have demonstrated anticonvulsive and even neuroprotective properties. In humans, low-dose ketamine has no influence on early cortical peaks of somatosensory evoked potentials (SEP). Larger doses induce increases in SEP amplitude while latencies are unchanged. Recent data indicate that analgesia induced by low-dose ketamine may be quantitated by...Continue Reading

Citations

Sep 15, 1998·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·A Pascual-LeoneM D Catalá
Apr 21, 2001·British Journal of Audiology·E SeifertA Lamprecht-Dinnesen
Aug 26, 2006·Anesthesia and Analgesia·Till SprengerKlaus J Wagner
Apr 25, 2012·Der Anaesthesist·R NitzschkeM S Goepfert
Apr 17, 2012·Anesthesia and Analgesia·Inga KüsterChristian Lehmann

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.