PMID: 9416727Jan 7, 1998Paper

Effects of ketamine on ventricular conduction, refractoriness, and wavelength: potential antiarrhythmic effects: a high-resolution epicardial mapping in rabbit hearts

Anesthesiology
A G AyaJ E de La Coussaye

Abstract

The aims of the study were to verify the effects of ketamine on ventricular conduction velocity and on the ventricular effective refractory period, to determine its effects on anisotropy and on homogeneity of refractoriness, and to use wavelength to determine whether ketamine has antiarrhythmic or arrhythmogenic properties. A high-resolution epicardial mapping system was used to study the effects of 50, 100, 150, and 200 microM racemic ketamine in 15 isolated, Langendorff-perfused rabbit hearts. Five hearts were kept intact to study the effects of ketamine on spontaneous sinus cycle length (RR) interval and its putative arrhythmogenic effects. In 10 other hearts, a thin epicardial layer was obtained by an endocardial cryoprocedure (frozen hearts) to study ventricular conduction velocity, ventricular effective refractory periods (five sites), and ventricular wavelength. Ketamine induced a concentration-dependent lengthening of the RR interval. Ketamine slowed longitudinal and transverse ventricular conduction velocity with no anisotropic change, and it prolonged the ventricular effective refractory period with no significant increase in dispersion. Ventricular longitudinal and transverse wavelengths tend to increase, but this wa...Continue Reading

References

Dec 1, 1979·British Journal of Anaesthesia·J IdvallP Stenberg
Mar 1, 1986·Journal of Cardiovascular Pharmacology·K SaegusaS Chiba
Feb 1, 1989·The American Journal of Physiology·E NiggliR Weingart
Jul 1, 1989·Anesthesiology·B RiouP Viars
Nov 1, 1988·The Journal of Physiology·W R Giles, Y Imaizumi
Jan 1, 1986·International Journal of Cardiac Imaging·M A AllessieR S Reneman
Sep 1, 1968·Anesthesiology·E G Dowdy, K Kaya
Feb 1, 1982·Anesthesiology·P F WhiteA J Trevor
May 1, 1994·Journal of Cardiovascular Pharmacology·V C BaumT S Klitzner

❮ Previous
Next ❯

Citations

Apr 12, 2005·Journal of Cardiovascular Pharmacology·Allyson J Bennett, Paolo B DePetrillo
Dec 25, 2012·Seminars in Cardiothoracic and Vascular Anesthesia·Jenny Kwak
Oct 3, 2014·Pediatric Emergency Care·Kristin S StukusDaniel M Cohen
Aug 16, 2016·Journal of Cardiovascular Pharmacology·Asya MakhroAnna Bogdanova
Apr 21, 2017·Frontiers in Medicine·Francesco CiconeJohn O Prior
Dec 17, 2014·Expert Opinion on Therapeutic Targets·Milica Bozic, José M Valdivielso
Aug 28, 2021·Frontiers in Psychiatry·Amir MeftahJoshua T Kantrowitz
Oct 7, 2008·Journal of Cardiothoracic and Vascular Anesthesia·Rony H AtiyehManuel R Castresana

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Anti-Arrhythmic Drug Therapies

Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.