PMID: 9438225Jan 23, 1998Paper

Effects of ketamine sedation on glucose clearance, insulin secretion and counterregulatory hormone production in baboons (Papio hamadryas)

Journal of Medical Primatology
R LehmannN S Kenyon

Abstract

Since the effects of ketamine sedation seem to differ between subspecies of baboons, we assessed the endocrine response to an intravenous glucose tolerance test (IVGTT) in 12 hamadryas baboons. The first phase insulin secretion, basal insulin, and glucose levels, as well as the glucose clearance, were significantly lower in sedated baboons as compared to fully awake animals. Glucagon and cortisol were significantly higher, while growth hormone was lower during ketamine sedation. Papio hamadryas appears to be a promising pre-clinical model for the study of endocrine replacement therapy in insulin-dependent diabetes. However, the data obtained must be interpreted with the knowledge that the anesthetic employed to allow for testing of the animals does have an effect on the parameters described in this report.

References

Jun 1, 1990·Hormones and Behavior·J Lovejoy, K Wallen
Apr 1, 1989·Nihon juigaku zasshi. The Japanese journal of veterinary science·M TagawaS Motoyoshi
Apr 1, 1988·Diabetes·C RicordiD W Scharp
Oct 1, 1987·Journal of Surgical Oncology·D F Du ToitR Gonin
Jan 1, 1986·Diabetes/metabolism Reviews·J O HolloszyD A Young
Feb 1, 1986·Medicine and Science in Sports and Exercise·E S Horton
Jan 1, 1973·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·S R BloomO E Pratt
Feb 9, 1984·The New England Journal of Medicine·C E Mogensen
Jul 12, 1984·The New England Journal of Medicine·C E Mogensen, C K Christensen
Mar 1, 1981·Diabetologia·D E Sutherland
Apr 1, 1981·Diabetologia·D E Sutherland
Dec 1, 1981·Proceedings of the Society for Experimental Biology and Medicine·M I CastroD Taub
Jan 1, 1995·Journal of Medical Primatology·S HeffernanJ Turtle
Feb 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J J BourgoignieT T Antonovych
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
Feb 1, 1997·Diabetologia·A SecchiG Pozza
Jan 1, 1982·American Journal of Primatology·Joseph W Kemnitz, Gary W Kraemer

❮ Previous
Next ❯

Citations

Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·N S KenyonC Ricordi
May 13, 2014·Journal of Medical Primatology·Jong Min KimChung-Gyu Park
Oct 20, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·T A LutzE Scharrer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

Related Papers

Journal of Pediatric Endocrinology & Metabolism : JPEM
Mauro BozzolaVittorio Locatelli
Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Young L KimSusan M Gapstur
The International Journal of Biochemistry
E D SaggersonC A Carpenter
© 2021 Meta ULC. All rights reserved