Effects of ketoacidosis and puberty on basal and TRH-stimulated thyroid hormones and TSH in children with diabetes mellitus

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
F ChiarelliG Morgese

Abstract

Basal and TRH-stimulated thyroid hormones and TSH were evaluated in two groups of prepubertal and pubertal diabetics: group B - 45 children without ketoacidosis; group C - 16 children with ketoacidosis. The diabetic patients showed no signs of diabetic microangiopathy. Fifty-three healthy subjects served as controls (group A). T4, T3, FT4 and FT3 serum levels were reduced in diabetics, particularly in ketotic ones; T4 and T3 values were lower in pubertal than in prepubertal non-ketotic diabetics and in pubertal than in prepubertal controls, while no significant difference was observed between pubertal and prepubertal ketotic patients. Moreover, no difference in rT3 serum concentrations was found between group A, B and C, but non-ketotic and ketotic pubertals showed a significant rT3 reduction if compared with non-ketotic and ketotic prepubertals and with healthy pubertals. TBG was lower in group B and group C diabetics than in controls. After TRH stimulus, T3 levels showed a significant increase both in controls and in non-ketotic diabetics, while no variation was observed in ketotic children; furthermore, at 120 minutes T3 values were lower in diabetic than in healthy children, particularly in ketotic ones. Basal TSH serum con...Continue Reading

Citations

Apr 1, 1997·Journal of Endocrinological Investigation·A MohnF Angrilli
Jun 5, 1999·International Journal of Clinical & Laboratory Research·A VerrottiF Chiarelli
Jul 25, 2000·Thyroid : Official Journal of the American Thyroid Association·F ChiarelliM de Martino
Jul 7, 1999·Journal of Pediatric Endocrinology & Metabolism : JPEM·F ChiarelliM de Martino
Jul 1, 2021·International Journal of Endocrinology·Yuling XingHuijuan Ma

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