Effects of ketorolac and dextran-70 alone and in combination on haemostasis

Acta Anaesthesiologica Scandinavica
I PowerI A Greer


Dextran may be used in surgical patients for thromboprophylaxis or volume expansion along with ketorolac, a nonsteroidal anti-inflammatory drug, for analgesia. As these two agents can influence the haemostatic system at different sites, it is important to demonstrate that there is no adverse haemostatic interaction between them. The haemostatic interaction between intravenous dextran-70 and intramuscular ketorolac was assessed in a double-blind, randomised, crossover study of healthy male volunteers each given all four combinations of ketorolac/placebo intramuscularly and dextran/placebo intravenously. The effect of ketorolac and dextran on haemostasis was assessed by the following techniques: skin bleeding time, in vitro platelet aggregation function, whole blood thromboxane generation, von Willebrand factor antigen, factor VIII coagulant activity and tissue plasminogen activator. The results were analysed for the effects of ketorolac and dextran and for any evidence of an interaction. Ketorolac inhibited platelet function and thromboxane generation. Dextran reduced factor VIII coagulant activity. Neither agent had a significant effect on bleeding time, von Willebrand factor or tissue plasminogen activator. There was only evid...Continue Reading


Aug 1, 1985·Acta Anaesthesiologica Scandinavica·D Bergqvist
Sep 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·R W KellyM J O'Sullivan
Sep 1, 1985·Prostaglandins, Leukotrienes, and Medicine·I A GreerC D Forbes
Sep 1, 1986·Prostaglandins, Leukotrienes, and Medicine·R W KellyR F Seamark
Sep 1, 1968·The Journal of Clinical Investigation·H J WeissS Kochwa
Jul 1, 1995·Thrombosis Research·P A Flordal, K G Ljungström

❮ Previous
Next ❯


❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

Journal of Perianesthesia Nursing : Official Journal of the American Society of PeriAnesthesia Nurses
M A Fiedler
Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie
E ZoucasS Bengmark
Journal of Neurosurgery
J TreibG Pindur
The British Journal of Surgery
B P HeatherR M Greenhalgh
© 2021 Meta ULC. All rights reserved