Effects of ketorolac and dextran-70 alone and in combination on haemostasis

Acta Anaesthesiologica Scandinavica
I PowerI A Greer

Abstract

Dextran may be used in surgical patients for thromboprophylaxis or volume expansion along with ketorolac, a nonsteroidal anti-inflammatory drug, for analgesia. As these two agents can influence the haemostatic system at different sites, it is important to demonstrate that there is no adverse haemostatic interaction between them. The haemostatic interaction between intravenous dextran-70 and intramuscular ketorolac was assessed in a double-blind, randomised, crossover study of healthy male volunteers each given all four combinations of ketorolac/placebo intramuscularly and dextran/placebo intravenously. The effect of ketorolac and dextran on haemostasis was assessed by the following techniques: skin bleeding time, in vitro platelet aggregation function, whole blood thromboxane generation, von Willebrand factor antigen, factor VIII coagulant activity and tissue plasminogen activator. The results were analysed for the effects of ketorolac and dextran and for any evidence of an interaction. Ketorolac inhibited platelet function and thromboxane generation. Dextran reduced factor VIII coagulant activity. Neither agent had a significant effect on bleeding time, von Willebrand factor or tissue plasminogen activator. There was only evid...Continue Reading

References

Aug 1, 1985·Acta Anaesthesiologica Scandinavica·D Bergqvist
Sep 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·R W KellyM J O'Sullivan
Sep 1, 1985·Prostaglandins, Leukotrienes, and Medicine·I A GreerC D Forbes
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Sep 1, 1968·The Journal of Clinical Investigation·H J WeissS Kochwa
Jul 1, 1995·Thrombosis Research·P A Flordal, K G Ljungström

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