Effects of Kombucha on oxidative stress induced nephrotoxicity in rats.

Chinese Medicine
Ola Ali Gharib

Abstract

Trichloroethylene (TCE) may induce oxidative stress which generates free radicals and alters antioxidants or oxygen-free radical scavenging enzymes. Twenty male albino rats were divided into four groups: (1) the control group treated with vehicle, (2) Kombucha (KT)-treated group, (3) TCE-treated group and (4) KT/TCE-treated group. Kidney lipid peroxidation, glutathione content, nitric oxide (NO) and total blood free radical concentrations were evaluated. Serum urea, creatinine level, gamma-glutamyl transferase (GGT) and lactate dehydrogenase (LDH) activities were also measured. TCE administration increased the malondiahyde (MDA) and NO contents in kidney, urea and creatinine concentrations in serum, total free radical level in blood and GGT and LDH activities in serum, whereas it decreased the glutathione (GSH) level in kidney homogenate. KT administration significantly improved lipid peroxidation and oxidative stress induced by TCE. The present study indicates that Kombucha may repair damage caused by environmental pollutants such as TCE and may be beneficial to patient suffering from renal impairment.

References

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Citations

May 18, 2012·BMC Complementary and Alternative Medicine·Ahmed AloulouEmna Ammar
Nov 14, 2012·Asian Pacific Journal of Tropical Medicine·Sundaraj RajamanikandanVelliyur Kanniappan Gopalakrishnan
Oct 5, 2017·Journal of Nephropathology·Mojgan HeydariKambiz Ahmadi Angali
Aug 20, 2020·Acta neurologica Belgica·Dariush HaghmoradParviz Kokhaei
Jul 1, 2014·Comprehensive Reviews in Food Science and Food Safety·Rasu JayabalanMuthuswamy Sathishkumar
Oct 27, 2021·Critical Reviews in Food Science and Nutrition·Mirian Aparecida de Campos CostaJosé Guilherme Prado Martin

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Methods Mentioned

BETA
electron paramagnetic resonance
ESR
MDA

Software Mentioned

GraphPad

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