Effects of Korean Red Ginseng extract on hepatic lipid accumulation in HepG2 cells

Bioscience, Biotechnology, and Biochemistry
Mak-Soon LeeYangha Kim

Abstract

In this study, we investigated the effects of Korean red ginseng water extract (KRGE) on hepatic lipid accumulation in HepG2 cells. KRGE decreased hepatic triglyceride and cholesterol levels. Further, KRGE suppressed expression of fatty acid synthase (FAS) and 3-hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase. These results suggest that KRGE may reduce hepatic lipid accumulation by inhibition of FAS and HMG-CoA reductase expression in HepG2 cells.

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Citations

Jun 26, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hyo Jin LeeOran Kwon

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Methods Mentioned

BETA
Assay
protein assay
PCR

Software Mentioned

SPSS

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