Effects of L-arginine on utero-placental circulation in growth-retarded fetuses

Acta Obstetricia Et Gynecologica Scandinavica
I NeriF Facchinetti

Abstract

To evaluate the effects of L-arginine (ARG) infusion, the nitric oxide as substrate, on the utero-placental circulation at third trimester. Three groups of nine pregnant women each were infused i.v. with 30 g ARG, for 30 minutes. One group served as control, and the two remnants were composed by patients with intrauterine growth retardation with (IUGR-B) or without (IUGR-A) increased resistances in the utero-placental circulation. Changes of blood flow velocity waveforms of both uterine arteries and umbilical artery were recorded for 60 minutes. Blood pressure, serum nitrites/nitrates and growth hormone levels were also measured. No hemodynamic changes in utero-umbilical circulation were observed during infusion in any of the three groups. Considering the uterine arteries separately as placental and non-placental sided we found a significant decrease of non-placental side resistances in IUGR-B women. Indeed, the pulsatility index was lowered by 14%, in respect of baseline value. Serum nitrites/nitrates as well as serum growth hormone levels were significantly increased by ARG, in every woman, irrespective of the presence of fetal growth retardation. Blood pressure remained unaffected during infusion in every woman. These findin...Continue Reading

References

Sep 15, 1990·Lancet·T NakakiR Kato
Sep 15, 1989·Biochemical and Biophysical Research Communications·C D LeafS R Tannenbaum
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L J IgnarroG Chaudhuri
Aug 1, 1967·The Journal of Clinical Endocrinology and Metabolism·M L ParkerW H Daughaday
Dec 30, 1993·The New England Journal of Medicine·S Moncada, A Higgs
Nov 1, 1993·American Journal of Obstetrics and Gynecology·C Yallampalli, R E Garfield
Nov 1, 1993·American Journal of Obstetrics and Gynecology·H IzumiR E Garfield
Jan 1, 1993·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·H ValensiseC Romanini

❮ Previous
Next ❯

Citations

Oct 2, 2012·Journal of Obstetrics and Gynaecology of India·Usha Krishna, Sarita Bhalerao
Aug 29, 2000·Obstetrics and Gynecology·C BenedettoF Facchinetti
Dec 5, 1998·Obstetrics and Gynecology·C C Lin, J Santolaya-Forgas
Aug 4, 2009·Reproductive Biology and Endocrinology : RB&E·Gloria ValdesJanae Joyner-Grantham
Jan 5, 2011·Frontiers in Bioscience (Scholar Edition)·Laura D BrownPaul J Rozance
Apr 11, 2009·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Norbert WinerDominique Darmaun
Dec 25, 2004·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·X M Xiao, L P Li
Jul 23, 2013·European Journal of Pharmacology·Noboru TodaTomio Okamura
Jun 20, 2015·Indian Journal of Clinical Biochemistry : IJCB·Shalini SinghJayashree Bhattacharjee
Mar 21, 1998·American Journal of Obstetrics and Gynecology·R J VosatkaK B Harvey-Wilkes
Aug 6, 2004·American Journal of Obstetrics and Gynecology·Malene R AndersenSteen Stender
Jun 7, 2006·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Isabella NeriFabio Facchinetti
Jan 7, 2009·Therapeutic Advances in Cardiovascular Disease·Patricio López-JaramilloMarcos López
May 4, 2004·Obstetrics and Gynecology·Héctor J LacassieHéctor López
Oct 23, 1997·British Journal of Obstetrics and Gynaecology·R Di IorioE V Cosmi
Apr 25, 2007·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Fabio FacchinettiAnnibale Volpe
Oct 21, 2010·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Isabella NeriFabio Facchinetti
Sep 17, 2004·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·I NeriF Facchinetti
Sep 16, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jose A Santiago-FontBabbette LaMarca

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
I NeriF Facchinetti
© 2021 Meta ULC. All rights reserved