Effects of L-carnitine on dialysis-related hypotension and muscle cramps: a meta-analysis

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Katherine E LynchSteven M Brunelli

Abstract

L-Carnitine is an endogenous compound thought to be helpful in treating patients with dialysis-related hypotension and muscle cramps; however, sufficient evidence for these indications is lacking. Systematic review and meta-analysis. Adult patients with end-stage renal disease receiving long-term hemodialysis. All published English-language reports of randomized placebo-controlled trials of L-carnitine supplementation in adult long-term hemodialysis patients. Supplemental L-carnitine (or placebo) for at least 8 weeks. Random-effects pooled odds ratio for intradialytic cramping or hypotension in L-carnitine-treated participants. Of 317 potentially relevant articles, 7 (total enrollment of 193 patients) met criteria for inclusion. Four articles reported results for both hypotension and cramps, 1 had results for only hypotension, and 2 reported results for only cramps. Using data from all 6 relevant trials, the pooled odds ratio for cramping after L-carnitine supplementation was 0.30 (95% confidence interval, 0.09 to 1.00; P = 0.05). Analysis of the 5 studies examining the response of intradialytic hypotension to l-carnitine supplementation yielded a pooled odds ratio of 0.28 (95% confidence interval, 0.04 to 2.23; P = 0.2). The s...Continue Reading

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