Effects of L-carnitine on oxidant/antioxidant status in acetic acid-induced colitis.

Digestive Diseases and Sciences
Ali CetinkayaYakup Gumusalan

Abstract

Recently, the role of oxidative stress in the pathogenesis of ulcerative colitis has been investigated. This study was designed to evaluate the possible beneficial effects of L-carnitine on tissue injury and oxidative stress in acetic acid-induced colitis in rats. Acetic acid administration induced severe damage macroscopically and histopathologically in colon and significantly increased the levels of malondialdehyde and myeloperoxidase in colonic tissue. Supplementation of L-carnitine to acetic acid-treated rats did not prove to induce any improvements in macroscopic scores, while L-carnitine administration improved histopathologic scores and significantly decreased malondialdehyde and myeloperoxidase levels in treatment groups. Acetic acid administration significantly decreased reduced glutathione, superoxide dismutase, and catalase levels in colonic homogenate. Supplementation of L-carnitine prevented the depletion of reduced glutathione levels but significantly increased superoxide dismutase levels. On the other hand, no significant change in catalase activity was observed. In conclusion, these results may reflect that L-carnitine could be beneficial as a complementary agent in treatment of ulcerative colitis.

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Sep 26, 1991·The New England Journal of Medicine·D K Podolsky
Feb 15, 1991·Clinica Chimica Acta; International Journal of Clinical Chemistry·J LoeperP Moisson
Jan 1, 1983·Annual Review of Pharmacology and Toxicology·I Fridovich
May 1, 1995·Metabolism: Clinical and Experimental·S LowittS Benford
Dec 1, 1995·Free Radical Biology & Medicine·G D Buffinton, W F Doe
Aug 1, 1995·Journal of Pineal Research·P T Pentney, G A Bubenik
Jun 1, 1996·Digestive Diseases and Sciences·C LoguercioC del Vecchio Blanco
Jul 1, 1996·The Journal of Clinical Investigation·S J McKenzieW F Doe
Nov 27, 1999·Life Sciences·V Nosál'ová, V Bauer
Jun 6, 2000·Journal of Toxicology and Environmental Health. Part a·F GirginT Tanyalçin
Oct 29, 2000·Digestive Diseases and Sciences·T R KochE C Opara
Oct 29, 2000·Digestive Diseases and Sciences·N NietoA Gil
Jul 27, 2001·The American Journal of Gastroenterology·A GiancateriniG Gasbarrini
Oct 24, 2001·Experimental Gerontology·P J Arockia Rani, C Panneerselvam
Oct 30, 2001·Digestive Diseases and Sciences·S ChoudharyA Banan
Nov 15, 2001·General Pharmacology·V Nosál'ováV Bauer
Feb 19, 2002·Kidney International·Marilena MisterGiuseppe Remuzzi
Mar 26, 2003·Journal of Toxicology and Environmental Health. Part a·Filiz KuralaySermin Ozkal
May 22, 2003·Drugs in R&D·Sundaram KumaranChinnakkannu Panneerselvam
Nov 8, 2003·World Journal of Gastroenterology : WJG·Wei-Guo DongJie-Ping Yu
Dec 12, 2003·World Journal of Gastroenterology : WJG·Shao-Ping LiuJie-Ping Yu
Jan 30, 2004·Journal of Gastroenterology and Hepatology·Kutbeddin DemirdagAhmet Kalkan
Apr 9, 2004·Journal of Cardiovascular Pharmacology·Göksel SenerAbdullah Sakarcan
Sep 24, 2004·Cell Biochemistry and Function·Sadik GörürGürbüz Polat

❮ Previous
Next ❯

Citations

Apr 28, 2011·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Makoto OoiMasaru Yoshida
Aug 7, 2012·Archives of Pharmacal Research·Xiao-Lai YangYong-Jie Wu
Sep 15, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Sonne R SrinivasPrem S Shekhawat
Sep 22, 2011·Canadian Journal of Surgery. Journal Canadien De Chirurgie·Gulgun TahanHafize Uzun
Aug 26, 2014·World Journal of Gastroenterology : WJG·Mahsa MoeinianMohammad Abdollahi
Feb 11, 2014·BMC Complementary and Alternative Medicine·Abdulaziz M AleisaMohammed M Ahmed
Sep 17, 2013·World Journal of Gastroenterology : WJG·Salim S Al-RejaieMohammed M Ahmed
Aug 30, 2008·Digestive Diseases and Sciences·Turhan DostMustafa Birincioglu
Jan 19, 2016·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Eman S H Abd AllahAmany O Mohamed
Jun 24, 2008·Journal of Ethnopharmacology·Hanan S El-AbharHala S Abdel Gawad
Feb 6, 2008·Fertility and Sterility·Hussein AbdelrazikAshok Agarwal
Jan 18, 2012·Alimentary Pharmacology & Therapeutics·M L Annunziata, S Hanauer
May 3, 2013·Animal Science Journal = Nihon Chikusan Gakkaihō·Teewara PhongnimitrRangsun Parnpai
Jun 26, 2015·Drug Development Research·Amal J FataniSalim S Al-Rejaie
Oct 28, 2014·Clinical Oral Investigations·A Harika Kutluay KöklüDilek A Uğar Çankal
Apr 6, 2011·Toxicology and Applied Pharmacology·K AmirshahrokhiM M Chinifroush
Jun 19, 2016·Lipids in Health and Disease·Bor-Jen LeePing-Ting Lin
Oct 28, 2016·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Gulistan Sanem SaribasCandan Ozogul
Apr 28, 2016·Journal of Gastroenterology and Hepatology·Yoshiyasu KonoHiroyuki Okada
Feb 2, 2018·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·O Yaman, Y Topcu-Tarladacalisir
Sep 2, 2014·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Puneet Kaur RandhawaAmteshwar Singh Jaggi
Nov 30, 2018·Toxicology Mechanisms and Methods·Mohita SharmaNaveen Kaushal
Mar 11, 2010·Medicine and Science in Sports and Exercise·Ioannis G FatourosVassilios Vargemezis
Jan 31, 2015·The Journal of Pharmacology and Experimental Therapeutics·Erin E WitalisonLorne J Hofseth
Nov 4, 2010·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·T KarsidagS Tuzun
Aug 9, 2020·Inflammatory Bowel Diseases·Nienke Z BorrenAshwin N Ananthakrishnan
Apr 25, 2020·Environmental Science and Pollution Research International·Mohamed AboubakrEhab Yahya Abdelhiee

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.