Effects of l-Carnitine on the Follicle-Stimulating Hormone, Luteinizing Hormone, Testosterone, and Testicular Tissue Oxidative Stress Levels in Streptozotocin-Induced Diabetic Rats

Journal of Evidence-based Integrative Medicine
Nourollah RezaeiZohre Zare

Abstract

The present study was designed to investigate the antioxidant property of l-carnitine (LC) on serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone (TH) and testis oxidative stress in streptozotocin (STZ)-induced diabetic rats. The rats were divided into the following groups: group I, control; group II, LC 100 mg/kg/d; group III, diabetic; and groups IV to VI, diabetic rats treated with 50, 100, and 200 mg/kg/d of LC, respectively. Daily injections were given intraperitoneally for 7 weeks. At the end of experimental period, after sacrificing the rats, FSH, LH, TH, total antioxidant capacity (TAC), malondialdehyde (MDA), glutathione (GSH), catalase (CAT), mitochondrial function (MTT), protein carbonyl (PC), and reactive oxygen species (ROS) levels were measured. STZ caused an elevation of MDA, ROS, and PC ( P < .001) with reduction of GSH, CAT, TAC, and MTT ( P < .001) in the serum levels. Group VI had significantly increased FSH, LH, and TH levels versus the untreated diabetic group ( P < .001). Although groups V and VI significantly decreased MDA ( P < .001), PC ( P < .01), and ROS ( P < .01) compared with the untreated diabetic group; only in group VI, the activity of GSH ( P < .001), CAT ...Continue Reading

References

Jan 1, 1984·Methods in Enzymology·H Aebi
Jun 1, 1981·International Journal of Andrology·J C SoufirP Jouannet
Aug 26, 1998·Annual Review of Nutrition·J Kerner, C Hoppel
Sep 4, 1998·Diabetes Care·A CerielloC Taboga
Jan 6, 1999·Seminars in Liver Disease·J C Fernández-ChecaA Colell
May 29, 2002·Diabetes Care·Kathryn C B TanKaren S L Lam
Apr 10, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shousong CaoYoucef M Rustum
Aug 5, 2004·Journal of Andrology·Joan BallesterJoan E Rodríguez-Gil
Mar 17, 2005·Journal of Agricultural and Food Chemistry·Dejian HuangRonald L Prior
May 20, 2005·Human & Experimental Toxicology·R YanardagO Karabulut-Bulan
Oct 29, 2005·Life Sciences·Ilhami Gülçin
Jan 26, 2006·Chemico-biological Interactions·Chidambaram PrahalathanPalaninathan Varalakshmi
Jan 31, 2006·Free Radical Biology & Medicine·Klas Blomgren, Henrik Hagberg
May 24, 2006·Free Radical Biology & Medicine·Kok Seong LimBarry Halliwell
Aug 18, 2006·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ibrahim KocerKorkmaz Serifoglu
Dec 6, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Edgar J RollemanMarion de Jong
Mar 6, 2007·Journal of Ethnopharmacology·Razieh YazdanparastShirin Jamshidi
Mar 27, 2007·Annals of the New York Academy of Sciences·M Ghazi-KhansariM-J Hosseini
Aug 19, 2008·Reviews in Endocrine & Metabolic Disorders·Claudia Figueroa-RomeroEva L Feldman
Jan 16, 2009·American Journal of Physiology. Renal Physiology·Christine Maric
May 7, 2010·Journal of Molecular Histology·Mehmet KanterSule Parlar
Apr 9, 2011·Journal of Andrology·Sandro La VigneraAldo E Calogero
Jan 12, 2013·Metallomics : Integrated Biometal Science·Mir-Jamal HosseiniJalal Pourahmad
Jul 23, 2013·Physiological Research·A BabicováJ Chládek
Jan 15, 2014·American Journal of Hypertension·Sonia ZambranoCarmen M Vázquez
Apr 18, 2014·Journal of Education and Health Promotion·Mohammad Asif
Oct 24, 2015·Cell Biology and Toxicology·Hamed FathiHamidreza Mohammadi

❮ Previous
Next ❯

Citations

Mar 17, 2021·Veterinary Medicine and Science·Rania A Abdel-Emam, Esraa A Ahmed

❮ Previous
Next ❯

Methods Mentioned

BETA
MDA
ELISA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.