PMID: 9416775Jan 1, 1997Paper

Effects of L-dopa and bromocriptine on haloperidol-induced motor deficits in mice

Life Sciences
T KobayashiY Oshima

Abstract

L-3,4-Dihydroxyphenylalanine (L-DOPA), the precursor of dopamine, and bromocriptine, a dopamine D2 receptor agonist, were investigated in haloperidol-induced motor impairments in mice using both catalepsy and pole tests. In catalepsy test, subcutaneous treatment with haloperidol (0.125, 0.25 and 0.5 mg/kg) caused a cataleptic effect in mice in a dose-dependent manner. This cataleptic effect was evident upto 7 hr after haloperidol treatment. In pole test, haloperidol (0.125, 0.25 and 0.5 mg/kg) produced the prolongation of Tturn and TLA as a marker of bradykinesia in mice and the prolongation lasted at least 7 hr after haloperidol treatment. Intraperitoneal co-pretreatment with L-DOPA (400 mg/kg) + carbidopa (10 mg/kg) in mice decreased the catalepsy induced by haloperidol at a dose of 0.125 mg/kg, while co-pretreatment with L-DOPA (200 and 400 mg/kg) + carbidopa (10 mg/kg) dose-dependently decreased the haloperidol (0.125 mg/kg)-induced bradykinesia. The effect of LDOPA + carbidopa in pole test was more pronounced than that in catalepsy test. Intraperitoneal pretreatment with bromocriptine (2 and 4 mg/kg) in mice reduced the catalepsy and bradykinesia produced by haloperidol at a dose of 0.125 mg/kg. The effect of bromocriptine...Continue Reading

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Citations

Apr 25, 2012·Psychopharmacology·Ilya D Ionov, Nicholas N Severtsev
Jan 5, 2002·Journal of Neuroscience Methods·Pierre O FernagutFrançois Tison
Oct 30, 2001·Behavioural Brain Research·M SedelisJ P Huston
Dec 25, 2002·Neurobiology of Aging·Rumiko KurosakiTsutomu Araki
Apr 21, 2001·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·T ArakiY Itoyama
Apr 14, 2011·British Journal of Pharmacology·Susan Duty, Peter Jenner
Jul 9, 2011·Neurochemistry International·Ozlem OzsoyMutay Aslan
Aug 19, 2003·Human Psychopharmacology·Marat G Uzbekov, Eduard Y Misionzhnik
Mar 25, 2009·International Journal of Immunopathology and Pharmacology·J KoniecznyM Pokorski
Apr 6, 2021·The European Journal of Neuroscience·Isabelle WakuAmanda R de Oliveira
May 26, 2004·Pharmacology, Biochemistry, and Behavior·Rumiko KurosakiTsutomu Araki

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