PMID: 2123121Aug 13, 1990Paper

Effects of L-dopa on extracellular dopamine in striatum of normal and 6-hydroxydopamine-treated rats

Brain Research
E D AbercrombieM J Zigmond

Abstract

In vivo microdialysis was used to examine the effect of L-3,4-dihydroxyphenylalanine (L-DOPA) administration upon dopamine (DA) in extracellular fluid both in intact striatum and in striatum of rats treated with the catecholaminergic neurotoxin 6-hydroxydopamine (6-HDA). Basal extracellular levels of DA were not significantly altered by 6-HDA unless the DA content of striatal tissue was reduced to less than 20% of control. Peripheral aromatic amino acid decarboxylase (AADC) inhibition (RO4-4602, 50 mg/kg i.p.) followed by L-DOPA treatment (100 mg/kg i.p.) elevated extracellular DA in striatum of control rats from 37 +/- 5 to 68 +/- 11 pg/sample (n = 7; values corrected for recovery of the dialysis probe). In animals with severe bilateral depletions of DA in striatal tissue (mean depletion 87%; n = 6), L-DOPA increased extracellular DA in striatum from 8 +/- 3 to 266 +/- 60 pg/sample. In animals with large unilateral depletions of DA in striatal tissue (mean depletion 96%; n = 6), the increase in extracellular DA in striatum after L-DOPA was greater on the lesion side (from 7 +/- 4 to 245 +/- 67 pg/sample) than on the intact side (from 28 +/- 11 to 61 +/- 8 pg/sample). Animals with unilateral DA depletions showed contralateral c...Continue Reading

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Citations

Apr 15, 2000·Synapse·S M PearlM J Zigmond
Aug 6, 2000·Movement Disorders : Official Journal of the Movement Disorder Society·J KulisevskyA Estévez-González
Jul 12, 2002·Annals of Neurology·John G NuttGary J Sexton
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May 27, 2009·Journal of Neural Transmission·Virgili PérezJaime Kulisevsky
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Jun 4, 1998·Pharmacology, Biochemistry, and Behavior·J KatajamäkiL Ahtee

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