PMID: 6407056Jan 1, 1983Paper

Effects of L-histidine and promethazine on apomorphine and amantadine stereotypy in rats

Psychopharmacology
J J BalsaraA G Chandorkar

Abstract

Pretreatment with L-histidine, a precursor of brain histamine, and promethazine, a H1 receptor blocker, failed to modify apomorphine-induced stereotyped behaviour in rats. In contrast, pretreatment with L-histidine significantly decreased the intensity of amantadine stereotypy while pretreatment with promethazine significantly increased the intensity of amantadine stereotypy in rats. The results suggest that drugs which influence central histaminergic mechanisms are effective only in modifying the stereotyped behaviour induced by the indirectly-acting DA agonist amantadine, and fail to modify the stereotyped behaviour induced by apomorphine, a directly-acting DA agonist.

References

Mar 1, 1976·The Journal of Pharmacy and Pharmacology·E Mogilnicka, C Braestrup
Aug 15, 1975·Life Sciences·J C Schwartz
May 15, 1977·European Journal of Pharmacology·N Subramanian, A H Mulder
Jan 1, 1974·Journal of Psychiatric Research·A Randrup, I Munkvad
Aug 15, 1971·Life Sciences. Pt. 1: Physiology and Pharmacology·R J Naylor, B Costall
Mar 1, 1973·European Journal of Pharmacology·B Costall, R J Naylor
Feb 1, 1972·Journal of Neurochemistry·K M Taylor, S H Snyder
Mar 1, 1972·Journal of Neurochemistry·J C SchwartzC Rose
Jan 1, 1970·Acta Pharmacologica Et Toxicologica·J Scheel-Krüger
Jan 1, 1968·Acta Pharmacologica Et Toxicologica·T Armfred, A Randrup
Mar 1, 1981·Neuropharmacology·C J Carter, C J Pycock

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