Effects of L-tryptophan on gastric emptying evaluated by breath test in relation to gastric accommodation evaluated by Barostat in rats

Journal of Pharmacological Sciences
Masayuki UchidaChizuru Iwamoto

Abstract

Gastric emptying has been known to correlate the pyloric sphincter contractile function and distention-induced gastric relaxation (gastric accommodation). In the present study, the effects of L-tryptophan on the gastric emptying and accommodation were evaluated by breath test using [1-(13)C]acetic acid and Barostat study, respectively, in rats. L-Tryptophan significantly decreased Cmax and AUC120min and delayed Tmax, indicating the inhibition of gastric emptying. L-Tryptophan significantly enhanced the gastric accommodation. These findings show that L-tryptophan may inhibit the gastric emptying through the enhanced gastric accommodation. Therefore, L-tryptophan may be useful for the therapy of postprandial dyspepsia, especially for early satiety.

References

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Aug 8, 2013·World Journal of Gastroenterology : WJG·Xiu-Ping FanYa-Jing Zhou

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Citations

Mar 25, 2017·Journal of Neurogastroenterology and Motility·Masayuki UchidaChizuru Saito
Aug 26, 2016·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Masayuki Uchida, Chizuru Iwamoto
Sep 1, 2017·BMC Complementary and Alternative Medicine·Xiongfei ChangShengsheng Zhang

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