PMID: 8590553Nov 1, 1995Paper

Effects of lactate infusion on hepatic gluconeogenesis and glycogenolysis

Clinical Physiology
E HaeslerL Tappy

Abstract

Endogenous glucose production rate (EGPR) remains constant when lactate is infused in healthy humans. A decrease of glycogenolysis or of gluconeogenesis from endogenous precursors or a stimulation of glycogen synthesis, may all be involved; This autoregulation does not depend on changes in glucoregulatory hormones. It may be speculated that alterations in basal sympathetic tone may be involved. To gain insights into the mechanisms responsible for autoregulation of EGPR, glycogenolysis and gluconeogenesis were measured, with a novel method (based on the prelabelling of endogenous glycogen with 13C glucose, and determination of hepatic 13C glycogen enrichment from breath 13CO2 and respiratory gas exchanges) in healthy humans infused with lactate or saline. These measurements were performed with or without beta-adrenergic receptor blockade (propranolol). Infusion of lactate increased energy expenditure, but did not increase EGPR; the relative contributions of gluconeogenesis and glycogenolysis to EGPR were also unaltered. This indicates that autoregulation is attained, at least in part, by inhibition of gluconeogenesis from endogenous precursors. beta-adrenergic receptor blockade alone (with propranolol) did not alter EGPR, glycog...Continue Reading

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Citations

Nov 2, 2002·The Journal of Physiology·Benjamin F MillerGeorge A Brooks
Jun 4, 2002·The Journal of Biological Chemistry·Keld FosgerauNiels Westergaard
Oct 8, 2005·Attachment & Human Development·Arietta SladeAlison Locker
Jan 11, 2007·American Journal of Physiology. Endocrinology and Metabolism·Peter StaehrBernard R Landau
Aug 15, 2014·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Teye OmlinJean-Michel Weber
Aug 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·L TappyM Berger
Aug 12, 1999·The Journal of Clinical Endocrinology and Metabolism·M T van der MerweP N Lönnroth
Jul 7, 2001·American Journal of Physiology. Endocrinology and Metabolism·K FosgerauR N Bergman
Jun 8, 2001·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·Luc TappyPhilippe Schneiter
Oct 12, 2002·American Journal of Physiology. Endocrinology and Metabolism·Benjamin F MillerGeorge A Brooks

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