Effects of lactational exposure to low-dose BaP on allergic and non-allergic immune responses in mice offspring

Journal of Immunotoxicology
Rie YanagisawaHirohisa Takano

Abstract

Benzo[a]pyrene (BaP) can induce developmental and reproductive toxicity; however, the full scope of its immunotoxic effects remains unknown. This study aimed to assess effects of lactational exposure to low-dose BaP (comparable to human exposure) on potential allergic\non-allergic immune responses in murine offspring. Lactating C3H/HeJ dams were orally dosed with BaP at 0, 0.25, 5.0, or 100 pmol/animal/week) at post-natal days [PND] 1, 8, and 15. Five-weeks-old pups then received intratracheally ovalbumin (OVA) every 2 weeks for 6 weeks. Following the final exposure, mice were processed to permit analyses of bronchoalveolar lavage (BAL) fluid cell profiles as well as levels of lung inflammatory cytokines and chemokines, serum OVA-specific immunoglobulin, and mediastinal lymph node (MLN) cell activation/proliferation. In OVA-sensitized male offspring, lactational low-dose BaP exposure led to enhanced (albeit not significantly) macrophage, neutrophil, and eosinophil infiltration to, and increased T-helper (TH)-2 cytokine production in, the lungs. In females, BaP exposure, regardless of dose, led to slightly enhanced lung levels of macrophages and eosinophils, and of inflammatory molecules. Protein levels of interleukin (IL)-33 in...Continue Reading

References

May 1, 1991·Toxicology and Industrial Health·H A Hattemer-Frey, C C Travis
Nov 1, 1994·Environmental Health Perspectives·L S Birnbaum
Apr 1, 1997·Brain & Development·N Gordon
Jul 1, 1997·American Journal of Respiratory and Critical Care Medicine·H TakanoM Sagai
Sep 29, 1999·The American Journal of Clinical Nutrition·J W AndersonD T Remley
Nov 22, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B N MelgertM N Hylkema
Feb 28, 2006·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R YanagisawaK Hayakawa
Mar 25, 2006·International Journal of Cancer. Journal International Du Cancer·Steen MollerupAage Haugen
Nov 8, 2007·Journal of Pharmacological Sciences·Nobuaki MizutaniShigekatsu Kohno
May 24, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·K OkuyamaI Ohno
Jul 25, 2008·Nature·Stephen J GalliAdrian M Piliponsky
Aug 12, 2008·Current Molecular Medicine·Yohannes Tesfaigzi
Jun 26, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mirjam KoolHamida Hammad
Jan 19, 2010·Nature Reviews. Immunology·Foo Y LiewIain B McInnes
Mar 27, 2010·Respirology : Official Journal of the Asian Pacific Society of Respirology·Kana WadaIsao Ohno
Apr 24, 2010·International Archives of Allergy and Immunology·M J BlacquièreB N Melgert
Apr 24, 2010·Allergology International : Official Journal of the Japanese Society of Allergology·Keisuke ObokiSusumu Nakae
Aug 3, 2013·Pharmacological Reviews·Francisco J Quintana, David H Sherr
Nov 5, 2013·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Eiko KoikeHirohisa Takano
Dec 18, 2013·The Journal of Allergy and Clinical Immunology·Wendy C MooreUNKNOWN National Heart, Lung, and Blood Institute's Severe Asthma Research Program
Apr 1, 2015·The Journal of Allergy and Clinical Immunology·Mingcan XiaTalal A Chatila
Feb 27, 2016·Journal of Applied Toxicology : JAT·Rie YanagisawaHirohisa Takano

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Citations

Nov 15, 2019·Current Opinion in Pulmonary Medicine·Annelies BontinckGuy Joos
Apr 15, 2020·Environmental Science and Pollution Research International·Yongyong FengShaolin Xie
Jan 22, 2021·Journal of Applied Toxicology : JAT·Tin-Tin Win-ShweHirohisa Takano
Aug 24, 2021·Human & Experimental Toxicology·Rie YanagisawaHirohisa Takano

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