PMID: 9532774Apr 9, 1998Paper

Effects of lactic acid bacteria on binding and absorption of mutagenic heterocyclic amines

Bioscience, Biotechnology, and Biochemistry
M TeraharaT Kaneko

Abstract

Effects of binding heterocyclic amines to cells of lactic acid bacteria on theirs absorption were investigated. Cells of Lactobacillus delbrueckii subsp. bulgaricus 2038 and Streptococcus thermophilus 1131 bind both 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1) and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx). The binding of strain 1131 cells to Trp-P-1 was maximum in the pHs from 4 to 8, but strain 2038 cells bound Trp-P-1 and MeIQx only slightly at pH 7. We investigated the absorption of heterocyclic amines by the small intestine of F344 rats in the presence of these bacterial cells, using an in situ loop technique. The absorption of Trp-P-1 by the small intestine was significantly lower in the presence of strain 1131 cells than in the absence of the cells, but the presence of strain 2038 cells had no effect on Trp-P-1 absorption. Perhaps strain 1131 cells bind to Trp-P-1 at the same pH as that of the small intestine (pH 6-7) and thus decrease its absorption.

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Citations

May 19, 2009·European Journal of Nutrition·Adriana Nowak, Zdzislawa Libudzisz
Sep 21, 2000·Chemico-biological Interactions·C HaskardJ Ahokas
Jan 27, 2010·World Journal of Gastroenterology : WJG·Silvia Wilson GratzHani S El-Nezami
Mar 16, 2002·Carcinogenesis·Emmanuelle TavanPierrette Cassand
Aug 17, 2000·Bioscience, Biotechnology, and Biochemistry·M TeraharaT Kaneko
Oct 21, 2017·Critical Reviews in Food Science and Nutrition·Zhao LiliZhang Bolin
Mar 6, 2008·Molecular Nutrition & Food Research·Reinhard StidlSiegfried Knasmüller
Mar 9, 1999·Journal of Dairy Science·P KontulaT Mattila-Sandholm
Sep 10, 2020·Critical Reviews in Food Science and Nutrition·P F Cuevas-GonzálezH S García
Mar 20, 2019·Mini Reviews in Medicinal Chemistry·Kianoush Khosravi-DaraniM Baghdadi

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