Effects of lactoferrin on IL-6 production by peritoneal and alveolar cells in cyclophosphamide-treated mice

Journal of Chemotherapy
Jolanta ArtymMarian L Kruzel

Abstract

Previous studies have shown that oral treatment with lactoferrin (LF) restores the immune response in cyclophosphamide (CP) immunocompromised mice. The aim of the present investigation was to determine the regulatory ability of LF on the production of interleukin 6 (IL-6) in peritoneal and alveolar cells, derived from CP-treated mice. CBA mice were injected with a single, intraperitoneal (i.p.) dose of CP (350 mg/kg body weight) followed by LF administered in drinking water (0.5% solution) for 21 days. The control counterparts were given water. Peritoneal and alveolar cells were isolated from mice and the production of IL-6, both spontaneous and lipopolysaccharide (LPS) induced, was determined in 24h cell cultures using a bioassay. The results showed increased production of IL-6 in both CP-treated mice and in mice given, in addition, LF. The administration of LF alone led also to an increase in IL-6 production by the cell cultures. Intravenous (i.v.) administration of LPS resulted in a significant increase in IL-6 serum levels in CP and CP/LF but not in LF-treated mice. Analysis of cell type composition in the peritoneal cavity revealed a strong increase in mastocyte and neutrophil content in CP and CP/LF-treated groups. Our fi...Continue Reading

References

Jan 1, 1989·Scandinavian Journal of Infectious Diseases·T J GuttebergT Jørgensen
Jun 3, 1999·Clinical Chemistry and Laboratory Medicine : CCLM·S BaveyeD Legrand
Dec 26, 2001·Antimicrobial Agents and Chemotherapy·R WiseJ M Andrews
Mar 23, 2002·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Hiroyuki TsudaMasaaki Ligo
Apr 19, 2002·International Immunopharmacology·Jeffrey K ActorMarian L Kruzel
Apr 27, 2002·Clinical Reviews in Allergy & Immunology·Ravi Malaviya, Amara Georges
May 7, 2002·Multiple Sclerosis : Clinical and Laboratory Research·H L Weiner, J A Cohen
Jul 16, 2002·Infection and Immunity·Erjian WangMichel G Bergeron
Sep 14, 2002·Annals of the Rheumatic Diseases·M J LeandroG Cambridge
Aug 30, 2003·Immunology Letters·Jolanta ArtymMarian L Kruzel

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Citations

Feb 10, 2010·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Dominique Legrand, Joël Mazurier
Mar 2, 2010·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Patrizia PudduSandra Gessani
Jul 16, 2008·The Journal of Surgical Research·Jose EngelmayerAtul Varadhachary
Nov 22, 2011·International Immunopharmacology·Maria Elisa Drago-SerranoRafael Campos-Rodríguez
Feb 13, 2008·Immunology and Cell Biology·Jagat R KanwarGeoffrey W Krissansen
Mar 3, 2012·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Theresa J OchoaThomas G Cleary
Dec 6, 2011·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Dominique Legrand
Feb 4, 2012·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Daniela LatorrePatrizia Puddu
Sep 11, 2007·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Kiyomi Takase, Izuru Kakuta
May 19, 2006·Reproductive Medicine and Biology·Kaori MitsukawaTakashi Okai
Aug 11, 2017·BMC Complementary and Alternative Medicine·Jinhee KimNo Soo Kim

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