PMID: 2492222Jan 1, 1989Paper

Effects of lamotrigine on electrically induced afterdischarge duration in anaesthetised rat, dog, and marmoset

Epilepsia
P Wheatley, A A Miller

Abstract

The effects of lamotrigine (LTG), a novel potent anticonvulsant, following intravenous (i.v.) bolus injection were studied on the durations of electrically induced afterdischarges of the EEG in halothane-anaesthetised dogs and marmosets, species used in toxicity studies. For comparison, the effect of LTG on hippocampal afterdischarge duration was also studied in halothane anaesthetised rats, a species in which the anticonvulsant action of LTG has been widely investigated. The known anticonvulsants phenytoin (PHT) and phenobarbital (PB) were included for comparison. LTG reduced afterdischarge duration in a dose-dependent manner in rat and dog; it was approximately twofold more potent than PHT in the dog and three- to fourfold more potent than PB in both dog and rat (LTG ED50 values = 4.5 and 11.7 mg.kg-1 i.v. in dogs and rats, respectively). PHT was ineffective in the rat at sublethal doses (less than 40 mg.kg-1 i.v.). In limited studies in marmosets, i.v. administration of both LTG and PHT (both 5-15 mg.kg-1) reduced or abolished afterdischarge. Thus, LTG was a potent anticonvulsant in rat, dog, and marmoset in afterdischarge models of partial (focal) seizures and may be of utility in the treatment of partial seizures in humans.

Citations

Jun 22, 2006·Neurotoxicity Research·T Archer, A Fredriksson
Mar 1, 1991·Neuropharmacology·R A O'Donnell, A A Miller
Oct 1, 1992·Epilepsy Research·L StankováP Mares
Mar 1, 1992·Seizure : the Journal of the British Epilepsy Association·T Betts
Dec 9, 2003·European Journal of Pharmacology·Margarida Castel-BrancoMargarida Caramona
May 4, 2004·Epilepsy Research·Jari NissinenAsla Pitkänen
Nov 11, 1998·European Journal of Pharmacology·E SouthamR M Hagan
Feb 27, 2003·Fundamental & Clinical Pharmacology·M M Castel-BrancoM M Caramona
Mar 1, 1995·Pharmacotherapy·A H Burstein
Jan 1, 1991·Epilepsia·M J LeachM A Critchley
Jan 1, 1995·Epilepsia·J A Messenheimer
Jun 6, 1992·Lancet·M J Brodie
Nov 9, 2016·Expert Review of Clinical Pharmacology·Venkata Ramesh YasamM J Nanjan
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Oct 1, 1994·Journal of Child Neurology·O DevinskyD Luciano
Nov 30, 2005·Fundamental & Clinical Pharmacology·M M Castel-BrancoM M Caramona

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