Effects of lamprey PQRFamide peptides on brain gonadotropin-releasing hormone concentrations and pituitary gonadotropin-β mRNA expression

General and Comparative Endocrinology
Dana DaukssStacia A Sower

Abstract

Within the RFamide peptide family, PQRFamide peptides that include neuropeptide FF and AF possess a C-terminal Pro-Gln-Arg-Phe-NH(2) motif. We previously identified PQRFamide peptides, lamprey PQRFa, PQRFa-related peptide (RP)-1 and -RP-2 by immunoaffinity purification in the brain of lamprey, one of the most ancient vertebrate species [13]. Lamprey PQRFamide peptide precursor mRNA was expressed in regions predicted to be involved in neuroendocrine regulation in the hypothalamus. However, the putative function(s) of lamprey PQRFamide peptides (PQRFa, PQRFa-RP-1 and PQRFa-RP-2) were not examined nor was the distribution of PQRFamide peptides examined in other tissues besides the brain. The objective of this study was to determine tissue distribution of lamprey PQRFamide peptide precursor mRNA, and to examine the effects of PQRFamide peptides on brain gonadotropin-releasing hormone (GnRH)-I, -II, and -III protein concentrations, and pituitary gonadotropin (GTH)-β mRNA expression in adult lampreys. Lamprey PQRFamide peptide precursor mRNA was expressed in the eye and the brain. Lamprey PQRFa at 100 μg/kg increased brain concentrations of lamprey GnRH-II compared with controls. PQRFa, PQRFa-RP-1 and PQRFa-RP-2 did not significantly...Continue Reading

References

Aug 12, 1977·Science·D A Price, M J Greenberg
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·H Y YangE Costa
Apr 5, 2002·The Journal of Experimental Zoology·Steven Q IrvineFrank H Ruddle
Sep 3, 2002·Mechanisms of Development·Verena D OehlmannSigrun I Korsching
Sep 10, 2003·The Journal of Biological Chemistry·Shoji FukusumiMasahiko Fujino
Sep 26, 2003·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Claudia FriedPeter F Stadler
Jan 24, 2006·General and Comparative Endocrinology·Stacia A SowerHiroshi Kawauchi
Jan 31, 2006·Peptides·Hsiu-Ying T Yang, Michael J Iadarola
May 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·Shinobu TakayasuJuro Sakai
Feb 5, 2008·Peptides·Estuardo López-VeraEdgar P Heimer de la Cotera
Aug 17, 2010·General and Comparative Endocrinology·Stacia A SowerScott I Kavanaugh

❮ Previous
Next ❯

Citations

Sep 16, 2014·General and Comparative Endocrinology·Takayoshi Ubuka, Kazuyoshi Tsutsui
Jul 3, 2015·General and Comparative Endocrinology·Tomohiro OsugiKazuyoshi Tsutsui
Jul 6, 2014·Frontiers in Endocrinology·Maurice R Elphick, Olivier Mirabeau
Feb 8, 2020·General and Comparative Endocrinology·José A Muñoz-CuetoYonathan Zohar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.