Effects of laser repetition rate on corneal tissue ablation for 193-nm excimer laser light

Lasers in Surgery and Medicine
Leia M ShanyfeltDavid W Hahn

Abstract

The goal of the present work is to assess whether bovine corneal ablations generated at laser repetition rates of up to 400 Hz are comparable to ablations performed at rates consistent with current clinical laser systems. A combination of experiments was used to assess a comprehensive range of ablation parameters, including ablation plume dynamics via imaging and transmission, corneal ablation profiles via scanning interferometry, and high-resolution electron microscopy of collagen structure following ablation. Using white-light interferometry analysis, no statistical difference was found between corneal ablation profiles created at 60 and 400 Hz, with an average rate of 0.94 microm/pulse at 60 Hz versus 0.92 microm/pulse at 400 Hz. In addition, based on plume imaging and transmission studies, the bulk ablation plume was found to dissipate on a time-scale less than the pulse-to-pulse separation for a laser repetition rate up to about 400 Hz. A persistent, diffuse gas-phase component of the ablation products was observed and concluded to be comparable at both repetition rates. Finally, SEM and TEM analysis revealed no signs of differential thermal tissue damage, including collagen fibril analysis, for laser repetition rates up t...Continue Reading

References

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Citations

Jun 3, 2010·Optics Letters·José R JiménezRosario G Anera
Jul 26, 2011·Journal of Cataract and Refractive Surgery·Sebastiano SerraoMarco Lombardo
Jul 27, 2010·Journal of Cataract and Refractive Surgery·Ramin KhoramniaChristoph Winkler von Mohrenfels
Mar 6, 2010·Journal of Cataract and Refractive Surgery·Christoph Winkler von MohrenfelsChris-Patrick Lohmann
Mar 4, 2011·Optics Express·Carlos DorronsoroSusana Marcos
Nov 26, 2015·Eye and Vision·Samuel Arba MosqueraColm McAlinden
Feb 8, 2018·Journal of Biomedical Optics·Samuel Arba-MosqueraShwetabh Verma
Oct 10, 2020·Journal of Refractive Surgery·Suphi TaneriH Burkhard Dick

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