Effects of lead and cadmium co-exposure on hemoglobin in a Chinese population

Environmental Toxicology and Pharmacology
Xiao ChenTaiyi Jin

Abstract

Cadmium (Cd) and lead (Pb) show adverse effects on hemoglobin. But most studies are focussed on one single agent. In this study, we observed the main and interactive effects of Cd and Pb on the hemoglobin level in a Chinese population. A total of 308 persons (202 women and 106 men), living in controlled and polluted areas, were included in this study. Blood and urine were collected to determine the levels of hemoglobin (Hb), Cd, Pb, and urinary N-acetyl-β-D-glucosaminidase (UNAG). The Cd and Pb level of subjects living in the polluted area were significantly higher compared to those living in the control area (p<0.05). The level of hemoglobin was declined with the increasing BPb (p<0.05) and BCd in women. The Hb of women and men with the highest level of BCd and BPb were decreased by 8.3g/L and 10.7 g/L compared to those with the lowest level of BCd and BPb, respectively. The Hb level of those women and men with the highest level of UNAG decreased by 4.2g/L and 17.2g/L compared with those with low level of UNAG, respectively. Hb was negatively associated with BPb, BCd, and UNAG. This study evidenced that Cd and Pb can influence Hb level. In addition, our study shows that Cd and Pb may have interactive effects on Hb and Hb level...Continue Reading

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Citations

Sep 2, 2015·ILAR Journal·Kun LuJames G Fox
Nov 5, 2016·Toxicology and Applied Pharmacology·Yandong ZhangYubin Zhang
Oct 17, 2017·Annals of Occupational and Environmental Medicine·Hyun Chan AnYangho Kim
Jun 23, 2019·Biological Trace Element Research·Zhenzhen PanLing Li
Jan 22, 2021·International Archives of Occupational and Environmental Health·Hongwu WangLian Ma
Mar 19, 2021·Environmental Analysis, Health and Toxicology·Lalit ChandravanshiSudhir Kumar
Jul 8, 2021·Ciência & saúde coletiva·Élida de Albuquerque CamposCarmen Freire Warden

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