Effects of lead and lead-melatonin exposure on protein and gene expression of metal transporters, proteins and the copper/zinc ratio in rats

Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
Karla J Soto-ArredondoMinerva Martínez-Alfaro

Abstract

Human lead (Pb) exposure induces many adverse health effects, including some related to lead accumulation in organs. Although lead bio-distribution in the body has been described, the molecular mechanism underlying distribution and excretion is not well understood. The transport of essential and toxic metals is principally mediated by proteins. How lead affects the expression of metal transporter proteins in the principal metal excretory organs, i.e., the liver and kidney, is unknown. Considering that co-administration of melatonin and lead reduces the toxic effects of lead and lead levels in the blood in vivo, we examined how lead and co-administration of lead and melatonin affect the gene and protein expression of metal transporter proteins (ZIP8, ZIP14, CTR1 and DMT1) in these organs. Rats were exposed intraperitoneally to lead or lead-melatonin. Our results show that Pb exposure induces changes in the protein and gene expression of ZIP8, ZIP14 and CTR1. Alterations in the copper/zinc ratio found in the blood, liver and kidney were likely related to these changes. With DMT1 expression (gene and protein), a positive correlation was found with lead levels in the kidney. Co-administration of melatonin and lead reduced lead-indu...Continue Reading

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Citations

Apr 9, 2020·Environmental Science and Pollution Research International·Samaila SalehMuhammad Azril Hezmi
May 24, 2019·Human & Experimental Toxicology·M S ManiH S Dsouza
Dec 19, 2019·Neotropical Entomology·E Juárez-HernándezJ Contreras-Garduño
Sep 20, 2020·Toxicology Letters·Monica Shirley ManiHerman Sunil Dsouza
Oct 13, 2018·Toxicology Letters·Piyawan PaisrisarnSuwimon Boonrungsiman
Apr 6, 2021·Neuroscience and Biobehavioral Reviews·Abraham Hernández-CoroFrancisca Pérez-Severiano
Aug 6, 2021·Journal of Biochemical and Molecular Toxicology·Carolina Ruiz-RamirezMinerva Martinez-Alfaro

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Methods Mentioned

BETA
PCR
Protein Assay

Software Mentioned

ImageLab
Sigma Stat
Systat

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