Effects of lead-contaminated sediment and nutrition on mallard duckling brain growth and biochemistry

Environmental Pollution
Erika K Douglas-StroebelL Sileo

Abstract

Day-old mallard (Anas platyryhnchos) ducklings received either a clean sediment (24%) supplemented control diet, Coeur d'Alene River Basin, Idaho (CDARB) sediment (3449 microg/g lead) supplemented diets at 12% or 24%, or a positive control diet (24% clean sediment with equivalent lead acetate to the 24% CDARB diet) for 6 weeks. The 12% CDARB diet resulted in a geometric mean concentration of 396 ppb (WW) brain lead with decreased brain protein and ATP concentrations but increased oxidized glutathione (GSSG) relative to the control diet. The 24% CDARB diet resulted in a concentration of 485 ppb brain lead with lower brain weight and ATP concentration than controls but higher concentrations of reduced glutathione (GSH) and calcium. Lead acetate accumulated twice as well as CDARB derived lead and resulted in histopathological lesions of the brain. With a combination of a suboptimal diet and 24% CDARB, brain lead concentration was higher (594 ppb) than with 24% CDARB in the standard diet, histopathological lesions became apparent and GSH was higher than suboptimal diet controls.

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Citations

Feb 1, 2006·Archives of Environmental Contamination and Toxicology·David J HoffmanDaniel J Audet
Jun 6, 2007·Archives of Environmental Contamination and Toxicology·Karin E Roux, Peter P Marra
Jul 15, 2006·Journal of Toxicology and Environmental Health. Part a·David J HoffmanDaniel J Audet
Mar 15, 2005·Journal of Toxicology and Environmental Health. Part a·Erika K Douglas-StroebelDavid J Hoffman
Aug 23, 2011·Ecotoxicology and Environmental Safety·Veronika PaskovaHilscherova Klara
Nov 18, 2018·The Science of the Total Environment·Stephanie C McClellandJordan Karubian
Dec 17, 2009·Environmental Science & Technology·Monica Martinez-HaroRafael Mateo

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