PMID: 8957382Dec 1, 1996Paper

Effects of left heart assist on geometry and function of the interventricular septum

The Annals of Thoracic Surgery
J G Markley, A C Nicolosi

Abstract

Right ventricular (RV) dysfunction is a common but poorly understood problem associated with mechanical left heart assist (LHA). Left ventricular unloading may affect RV function even in normal hearts by altering geometry or function of the interventricular septum, although such changes have not been well defined. Accordingly, the purposes of this study were to quantify the effects of LHA on septal geometry and function in normal swine and to assess the resultant effects on RV function. Domestic swine (50 kg, n = 10) were anesthetized and instrumented for collection of physiologic data and for open-chest LHA, which was accomplished by left atrial to subclavian artery bypass using a centrifugal pump. Both global and regional RV function data as well as two-dimensional echocardiographic data of septal geometry and function were collected at control levels and during both partial and full LHA. Short-axis echocardiographic images were obtained at the midventricular level and analyzed to quantify septal curvature (k; cm-1), systolic septal thickening (%), and systolic septal excursion (cm). Partial LHA had no effect on either septal geometry or function. Full LHA resulted in decreased diastolic septal curvature (k = 0.10 +/- 0.07 ve...Continue Reading

References

Jul 1, 1992·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·A KawaiB P Griffith

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Citations

Nov 8, 2008·IEEE Transactions on Bio-medical Engineering·Jonathan P MynardJoseph J Smolich
Aug 5, 2000·The Journal of Thoracic and Cardiovascular Surgery·M K Karunanithi, M P Feneley
Apr 4, 2006·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Philip J MaloufDaniel G Blanchard
Mar 27, 2003·The Journal of Thoracic and Cardiovascular Surgery·Boudewijn P J LeeuwenburghJan Baan
May 23, 2016·Interactive Cardiovascular and Thoracic Surgery·Marcin MalinowskiTomasz A Timek
Jan 25, 2006·Asian Cardiovascular & Thoracic Annals·S Kant
Aug 23, 2007·Seminars in Cardiothoracic and Vascular Anesthesia·Marc E Stone
Jan 29, 2003·Anesthesiology·Alfred C Nicolosi, Paul S Pagel

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