Effects of left ventricular systolic function on left ventricular diastolic filling patterns in severe mitral regurgitation

The American Journal of Cardiology
A SadaniantzA F Parisi

Abstract

Significant mitral regurgitation (MR) may alter the normal pattern of Doppler detected left ventricular (LV) filling by causing a prominent early filling (E) wave velocity. The manner and extent to which the typical filling pattern of uncomplicated MR is affected by concomitant impaired LV systolic function has not been characterized. Twenty patients with severe LV systolic dysfunction (2-dimensional echocardiographic estimation of ejection fraction < or = 30%) and 21 age- and sex-matched case controls with normal systolic function (ejection fraction > or = 55%) were selected. In addition, 20 subjects with normal LV systolic function and no MR were analyzed as a reference group. Maximal E-wave velocity was increased and highest among MR patients with preserved LV systolic function (124 +/- 37 cm/s) than among those with LV systolic dysfunction (101 +/- 25 cm/s; p <0.05) and normal controls (74 +/- 18 cm/s; p <0.001). Concurrently, A-wave velocity was lowest in patients with systolic dysfunction and MR (47 +/- 23 cm/s; p <0.001) than in patients with normal systolic function and MR (79 +/- 33 cm/s) and normal controls (74 +/- 20 cm/s). Deceleration time of the E wave was longest among those with normal systolic function and MR (...Continue Reading

References

Feb 1, 1992·Journal of the American College of Cardiology·P D ThompsonP S Douglas
Sep 1, 1989·American Heart Journal·G D Plotnick
Jan 1, 1995·European Heart Journal·A ManteroA Lippolis
Jul 1, 1994·Journal of the American College of Cardiology·G Y XieA N DeMaria

❮ Previous
Next ❯

Citations

Jul 3, 2007·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Alexander N BorgSimon G Ray
Feb 24, 2011·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Sherif E MoustafaFarouk Mookadam
Jun 18, 2009·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Alexander N BorgSimon G Ray
Feb 27, 2010·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Alexander N BorgSimon G Ray
Mar 31, 2011·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Sherif E MoustafaFarouk Mookadam
Mar 20, 2014·Circulation. Cardiovascular Imaging·Salim HayekAndreas P Kalogeropoulos

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.