Effects of length change on intracellular Ca2+ transients in ferret ventricular muscle treated with 2,3-butanedione monoxime (BDM)

The Japanese Journal of Physiology
S KuriharaN Sudo

Abstract

Quick release of the right ventricular papillary muscle of ferrets, injected with aequorin, from Lmax (initial length) to 92% Lmax during twitch response produced an extra-light signal of aequorin. 2,3-Butanedione monoxime (BDM) at 10 mM decreased the peak tension to less than 10% of that in control and the light signal to 70%. In the BDM-treated muscle, the extra-light in response to the quick release did not occur. A quick stretch from Lmax to 103% Lmax, in the presence and absence of BDM, did not cause any changes in the light signal. The results indicate that the extra-light signal in the quick release is tension dependent. The tension reduction by the quick release decreases the affinity of troponin-C (Tn-C) for Ca2+ without affecting Ca2+ handling system in intact cardiac muscle.

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Citations

Jun 1, 1994·Pharmacology & Toxicology·L C Sellin, J J McArdle
Mar 28, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Tetsuya IshikawaSatoshi Kurihara
Dec 3, 2005·Journal of Muscle Research and Cell Motility·Rene VandenboomJames D Hannon
Jun 27, 2017·Progress in Biophysics and Molecular Biology·Patrick SchönleitnerGudrun Antoons
Apr 26, 2003·American Journal of Physiology. Heart and Circulatory Physiology·So-ichiro YasudaHaruo Sugi
Apr 4, 2000·Physiological Reviews·A M GordonM Regnier
May 17, 2002·Journal of Applied Physiology·Ying Wang, W Glenn L Kerrick
Jan 14, 1999·The American Journal of Physiology·T IshikawaS Kurihara
Feb 12, 1998·The American Journal of Physiology·K KomukaiS Kurihara

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