Effects of leptin and corticosterone on the expression of corticotropin-releasing hormone, agouti-related protein, and proopiomelanocortin in the brain of ob/ob mouse

Neuroendocrinology
K ArvanitiDenis Richard

Abstract

The present study was conducted to assess the effect of leptin and corticosterone on the expression of corticotropin-releasing hormone (CRH), proopiomelanocortin (POMC) and agouti-related protein (AGRP) in the mouse brain. To this end, a 3 x 3 factorial experiment was designed in which adrenalectomized (ADX) ob/ob mice were treated with leptin and corticosterone. Leptin and corticosterone downregulated CRH expression in the paraventricular hypothalamic nucleus (PVH). Leptin prevented the stimulating effects of ADX on the expression of CRH and the combination of small doses of leptin and corticosterone was as potent as the high dose of corticosterone in suppressing CRH mRNA expression in the PVH. Leptin and corticosterone enhanced the expression of CRH in the central nucleus of amygdala and in the bed nucleus of the stria terminalis. In addition, the present results confirmed the downregulating effects of leptin on the expression of AGRP mRNA in the hypothalamic arcuate nucleus (ARC), and demonstrated that this effect was more apparent in ADX mice treated with corticosterone than in ADX mice not supplemented with corticosterone. Also, leptin and corticosterone had opposite effects on the expression of POMC in the ARC. The opposi...Continue Reading

Citations

Aug 2, 2012·Cellular and Molecular Life Sciences : CMLS·Carol F Elias, Darshana Purohit
May 24, 2005·Brain Research·Sami DridiJohan Buyse
Nov 19, 2003·European Journal of Pharmacology·Martien J H KasRoger A H Adan
Sep 5, 2003·Life Sciences·Li-Qiang QinTakashi Kaneko
Jun 26, 2003·Trends in Pharmacological Sciences·Roger A H Adan, Martien J H Kas
Aug 23, 2002·Behavioural Brain Research·Stephanie FultonPeter Shizgal
Jun 15, 2007·Current Opinion in Clinical Nutrition and Metabolic Care·Nicolas Rohleder, Clemens Kirschbaum
Nov 2, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Paul R BurghardtJon-Kar Zubieta
Jun 12, 2002·Canadian Journal of Physiology and Pharmacology·James E BlevinsDenis G Baskin
May 1, 2012·General and Comparative Endocrinology·Marnix GorissenGert Flik
Feb 2, 2012·General and Comparative Endocrinology·Eric W RoubosLu Xu
Mar 8, 2016·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Danusa Mar ArcegoCarla Dalmaz
Aug 25, 2007·Biological Psychiatry·Lucianne GroeninkBerend Olivier
Jan 11, 2007·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M D KlokM L Drent
Dec 14, 2011·The Journal of Pharmacy and Pharmacology·Walter MilanoAnna Capasso
May 12, 2004·Peptides·Sarah F Leibowitz, Katherine E Wortley
Apr 27, 2005·Endocrinology and Metabolism Clinics of North America·Lauren Jacobson
Oct 6, 2012·Stress : the International Journal on the Biology of Stress·Zeba HaqueDarakhshan J Haleem
May 3, 2008·Behavioural Brain Research·Elizabeth A LevayStephen Kent
Nov 12, 2014·Frontiers in Psychology·Clara RossettiBenjamin Boutrel
Nov 8, 2011·Neuroendocrinology·Elena ValassiMadhusmita Misra
Jun 24, 2010·Eating and Weight Disorders : EWD·A Stunkard, X-Y Lu
Dec 10, 2016·The Journal of Endocrinology·Liping Luo, Meilian Liu
May 28, 2019·Frontiers in Neuroscience·Xiaohan ZouBingjin Li
Sep 7, 2021·Physiological Reviews·Alan G WattsWolfgang Langhans

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