Effects of lesion of the inferior olivary complex in learning of the equilibrium behavior in the young rat during ontogenesis. I. Total lesion of the inferior olive by 3-acetylpyridine

Brain Research
N JonesJ Caston

Abstract

Young DA/HAN strain rats were submitted to an equilibrium test consisting in maintaining equilibrium upon a rotorod rotating at 10 or 20 rpm. They were either intact or lesioned, the lesion consisting in destruction of the inferior olivary complex (IOC) by 50-95 mg/kg i.p. administration of 3-acetylpyridine (3-AP) at day 15, followed, 2 to 4 h later, by i.p. injection of niacinamide (300 mg/kg). All the 3-AP-treated animals included in this study were completely lesioned, the extent of the lesion being estimated by both the response of the rats to harmaline and histological controls at the end of the experiments. The IOC lesioned rats were either naive (tested at one given day) or trained every day (10 trials per day); among the latters, some were trained before and after the lesion, the others being trained either before or only after. Control rats were submitted to the same training schedule. Both quantitative (time during which the animals maintained the equilibrium upon the rotating rod) and behavioral data (strategy used by the animals to maintain equilibrium) were obtained. The results demonstrate that, compared to those of controls rats, the quantitative and behavioral scores of the IOC lesioned animals were altered. Com...Continue Reading

Citations

Jan 29, 2000·Neuroscience and Behavioral Physiology·V V FanardzhyanO V Govorkyan
Apr 25, 2015·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Robert Lalonde, Catherine Strazielle
May 8, 1999·The American Journal of Physiology·B J BiesiadeckiS L Britton
Aug 28, 2021·International Journal of Environmental Research and Public Health·Kanae HiyoshiSachiko Tsuda
Oct 15, 2021·Scientific Reports·Tetsuro FunatoDai Yanagihara

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