Effects of lesions in the mesial frontal cortex on bimanual co-ordination in monkeys

Neuroscience
O KazennikovM Wiesendanger

Abstract

The hypothesis was tested that the mesial frontal cortex, including the supplementary motor area, is engaged in bimanual co-ordination. Three monkeys, trained in a well-co-ordinated bimanual pull-and-grasp task, were subjected to unilateral or bilateral lesions of the mesial frontal cortex. With unilateral lesions, the deficit consisted in a delay in movement initiation of the contralateral arm. With a bilateral lesion, the deficit was more pronounced with marked bilateral delays in movement onset and slowing in reaching. However, in the three monkeys bimanual co-ordination at the moment of goal achievement remained intact with an excellent temporal co-variation of the two limbs. In the two unilateral cases, an adaptive strategy developed after a few sessions, either by catching up during reaching with the limb contralateral to the lesion (monkey M1) or by delaying movement initiation of the limb ipsilateral to the lesion (monkey M2). This outcome is discussed in terms of Lashley's principle of motor equivalence, i.e. invariant goal achievement with variable means. Bilateral lesions led to a transient and near-total impairment in movement self-initiation when all external cues were absent. It is concluded that in monkeys the me...Continue Reading

References

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Citations

Apr 19, 2011·Experimental Brain Research·Deirdre BirtlesOliver Braddick
Sep 4, 1999·Behavioural Brain Research·S PerrigM Wiesendanger
May 4, 2002·Nature Reviews. Neuroscience·Stephan P Swinnen
May 23, 2012·Cerebral Cortex·Jörn DiedrichsenJohn W Krakauer
Feb 26, 2000·Neuropsychologia·D J Serrien, M Wiesendanger
Jul 1, 2011·Research in Developmental Disabilities·Ya-Ching HungAndrew M Gordon
Oct 20, 2007·The Journal of Physiology·Claudio BabiloniFabrizio Eusebi
Aug 23, 2008·NeuroImage·R R WalshA Solodkin
Nov 26, 2008·Human Movement Science·Andrea H Mason, Jennifer L Bruyn
Dec 5, 2003·Progress in Brain Research·Mario Wiesendanger, Deborah J Serrien
Jun 29, 2004·NeuroImage·Susan KoenekeLutz Jäncke
Aug 14, 2012·Journal of the International Neuropsychological Society : JINS·Adam D FalchookKenneth M Heilman
May 19, 2006·Journal of Neurophysiology·Ksenia I UstinovaMindy F Levin
Sep 27, 2001·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·M Wiesendanger, D J Serrien

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