Effects of lesions of the nigrostriatal pathway and of nigral grafts on striatal serotonergic innervation in adult rats

Neuroreport
M J GuerraJ L Labandeira-Garcia

Abstract

Neonatal destruction of the nigrostriatal dopaminergic system leads to serotonergic hyperinnervation of the striatum. However, it is not clear whether this occurs in adult animals. We investigated whether serotonergic sprouting occurs in adult animals, and also studied the effects of prior or subsequent implantation of dopamine-rich intrastriatal grafts. One group of adult rats received maximal 6-hydroxydopamine lesions. Other rats received maximal lesions and intrastriatal grafts 2 months later, or vice versa. The lesioned non-grafted rats showed clear serotonergic hyperinnervation throughout the striatum ipsilateral to the lesion. Intrastriatal grafts did not prevent or revert this serotonergic hyperinnervation, and were themselves densely innervated by serotonergic fibers. Serotonergic neurons usually present in the grafted cell suspension also contributed to the serotonergic innervation of the graft and the surrounding striatum.

Citations

May 12, 2005·Brain Research. Developmental Brain Research·Miles Gregory CunninghamFrancine Mary Benes
Mar 29, 2001·Neuroscience·A LopezJ L Labandeira-Garcia
Jul 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Ayse UlusoyDeniz Kirik
Jun 28, 2014·Neurobiology of Disease·Kuldip D DaveMark A Frasier
Mar 10, 2015·ACS Chemical Neuroscience·Vera NiederkoflerSusan M Dymecki
Sep 1, 2006·Journal of Neurochemistry·M Angela Cenci, Martin Lundblad
Jun 15, 2011·Parkinsonism & Related Disorders·Catherine BédardMartin Parent
Jun 6, 2018·Frontiers in Neuroanatomy·Dave GagnonMartin Parent
Aug 7, 2021·Brain Sciences·Maryann N KraskoMichelle R Ciucci

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