PMID: 6401835Jan 17, 1983Paper

Effects of leucine-enkephalin on hypothalamic-pituitary-thyroid axis in rats

Life Sciences
T Mitsuma, T Nogimori

Abstract

Basal thyrotropin (TSH) levels in plasma and the TSH response to thyrotropin-releasing hormone (TRH) were inhibited after Leucine-enkephalin (L-EK) administration iv in rats. TRH and TSH responses to cold were inhibited after L-EK administration. In the L-DOPA, haloperidol or 5-hydoxytryptophan-treated rats, the inhibitory effect of L-EK on TSH release was restored. Findings suggested that L-EK acted both the hypothalamus and pituitary. Its inhibitory effects on TRH and TSH release at least partially mediated by interaction with amines in the central nervous system.

References

Sep 4, 1978·Life Sciences·G R van Loon, E B De Souza
May 1, 1982·Acta Endocrinologica·T Mitsuma, T Nogimori
Jun 1, 1982·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·T Mitsuma, T Nogimori

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Citations

Jun 15, 1984·European Journal of Pharmacology·T MitsumaM Chaya
Jan 1, 1986·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·M L Leret, A Fraile
May 18, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Traci A CzyzykRuben Nogueiras

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