PMID: 11339501May 8, 2001Paper

Effects of leukotriene B4 receptor antagonist, LY293111Na, on antigen-induced bronchial hyperresponsiveness and leukocyte infiltration in sensitized guinea pigs

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
F AsanumaY Hori

Abstract

LY29311 Na, 2-[2-propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy] propoxy] -phenoxy]-benzoic acid sodium salt, is a novel leukotriene B4 (LTB4) receptor antagonist. Its effects on guinea pig models of asthma were compared with those of dexamethasone. Effects of LY293111Na were tested in antigen (ovalbumin, OA)-induced bronchial hyperresponsiveness (BHR) and leukocyte accumulation in actively sensitized guinea pigs. Its effects on antigen-induced acute bronchoconstriction in passively sensitized guinea pigs were also studied. LY293111 Na (10 to 30 mg/kg p.o., 1 h before and 6 h after OA challenge) inhibited BHR to acetylcholine. LY293111 Na (3 mg/kg p. o.) significantly inhibited accumulation of neutrophils in bronchoalveolar lavage (BAL) fluid 24 h after antigen challenge but it did not inhibit accumulation of eosinophils and macrophages at any doses used. In contrast, dexamethasone (30 mg/kg p.o., 4 h before OA challenge) not only inhibited BHR but also reduced the infiltration of all three types of leukocytes. A significant increase of LTB4 levels in BAL fluid was noted at 3 and 15 min after the antigen challenge. LY293111Na did not inhibit antigen-induced acute bronchoconstriction in passively sensitized guinea pigs...Continue Reading

Citations

Jan 28, 2005·Journal of Biochemical and Molecular Toxicology·Carol L K SabourinJohn J Schlager
Mar 26, 2008·Proceedings of the National Academy of Sciences of the United States of America·Richard EinsteinStephen B Liggett
Jul 25, 2014·Drugs·Rachid Berair, Christopher E Brightling
Sep 18, 2008·Allergology International : Official Journal of the Japanese Society of Allergology·Hiroshi OhnishiErwin W Gelfand
Jan 13, 2015·Allergology International : Official Journal of the Japanese Society of Allergology·Min Liu, Takehiko Yokomizo
Feb 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christian TaubeErwin W Gelfand
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Jul 25, 2019·International Journal of Molecular Sciences·Airi Jo-WatanabeTakehiko Yokomizo
May 6, 2020·International Journal of Molecular Sciences·Joana VitalléOlatz Zenarruzabeitia

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